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A Pilot Study on Daily Intensive ECT over 8 Days Improved Positive and Negative Symptoms and General Psychopathology of Patients with Treatment-Resistant Schizophrenia up to 4 Weeks after Treatment
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 4509708
Author(s) Davarinejad, Omran; Hendesi, Koorosh; Shahi, Hassan; Brand, Serge; Khazaie, Habibolah
Author(s) at UniBasel Brand, Serge
Year 2019
Title A Pilot Study on Daily Intensive ECT over 8 Days Improved Positive and Negative Symptoms and General Psychopathology of Patients with Treatment-Resistant Schizophrenia up to 4 Weeks after Treatment
Journal Neuropsychobiology
Volume 78
Number 1
Pages / Article-Number 58-58
Keywords Cognitive functions; Electroconvulsive therapy; Intensive treatment; Positive and negative symptoms; Treatment-resistant schizophrenia
Mesh terms Adult; Cognition; Drug Resistance; Electroconvulsive Therapy, methods; Female; Follow-Up Studies; Humans; Male; Pilot Projects; Psychiatric Status Rating Scales; Schizophrenia, therapy; Schizophrenic Psychology; Time Factors; Treatment Outcome
Abstract For patients with treatment-resistant schizophrenia (TRS) who do not respond to drug therapy, electroconvulsive therapy (ECT) is often employed as an additional treatment. The aims of the present study were to investigate to what extent an 8-day daily ECT treatment might reduce symptoms of schizophrenia among patients with TRS both in the short term (end of the treatment) and medium term, that is 4 and 12 weeks after the treatment.; Fourteen patients with TRS based on DSM-5 criteria took part in the present study. ECT consisted of daily sessions for 8 consecutive days. At baseline, at the end of the intervention, and 4 and 12 weeks after study completion, trained psychiatrists assessed the patients' disease severity (positive and negative symptoms; psychopathology) and cognitive functions.; Disease symptoms (positive and negative symptoms; psychopathology) became reduced from baseline to the end of the intervention and to 4 weeks after treatment. Twelve weeks after the intervention symptoms again increased. Cognitive functions decreased from baseline to the end of the study and 4 weeks after treatment. However, by 12 weeks after the intervention, cognitive functions had returned to baseline levels.; The pattern of results suggests that an intensive 8-day daily course of ECT reduced psychiatric symptoms (positive and negative symptoms, psychopathology) in both the short and medium term among patients with TRS. The increase in symptoms between 4 and 12 weeks following intervention suggests that booster sessions of ECT could be beneficial.
Publisher S. Karger
ISSN/ISBN 1423-0224
edoc-URL https://edoc.unibas.ch/71425/
Full Text on edoc No
Digital Object Identifier DOI 10.1159/000494698
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/30463074
ISI-Number WOS:000468271800008
Document type (ISI) Correction
 
   

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