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Brainstem Circuits Controlling Action Diversification
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 4509462
Author(s) Ruder, Ludwig; Arber, Silvia
Author(s) at UniBasel Arber, Silvia
Year 2019
Title Brainstem Circuits Controlling Action Diversification
Journal Annual review of neuroscience
Volume 42
Pages / Article-Number 485-504
Keywords brainstem; locomotion; motor control; neuronal cell types; orofacial behavior; skilled forelimb movement
Abstract Neuronal circuits that regulate movement are distributed throughout the nervous system. The brainstem is an important interface between upper motor centers involved in action planning and circuits in the spinal cord ultimately leading to execution of body movements. Here we focus on recent work using genetic and viral entry points to reveal the identity of functionally dedicated and frequently spatially intermingled brainstem populations essential for action diversification, a general principle conserved throughout evolution. Brainstem circuits with distinct organization and function control skilled forelimb behavior, orofacial movements, and locomotion. They convey regulatory parameters to motor output structures and collaborate in the construction of complex natural motor behaviors. Functionally tuned brainstem neurons for different actions serve as important integrators of synaptic inputs from upstream centers, including the basal ganglia and cortex, to regulate and modulate behavioral function in different contexts.
Publisher ANNUAL REVIEWS
ISSN/ISBN 0147-006X ; 1545-4126
edoc-URL https://edoc.unibas.ch/71351/
Full Text on edoc Available
Digital Object Identifier DOI 10.1146/annurev-neuro-070918-050201
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/31283898
ISI-Number WOS:000483393600023
Document type (ISI) Journal Article
 
   

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