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An In Vitro Study of Osteoblast Response on Fused-Filament Fabrication 3D Printed PEEK for Dental and Cranio-Maxillofacial Implants
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 4508459
Author(s) Han, Xingting; Sharma, Neha; Xu, Zeqian; Scheideler, Lutz; Geis-Gerstorfer, Jürgen; Rupp, Frank; Thieringer, Florian M.; Spintzyk, Sebastian
Author(s) at UniBasel Thieringer, Florian Markus
Year 2019
Title An In Vitro Study of Osteoblast Response on Fused-Filament Fabrication 3D Printed PEEK for Dental and Cranio-Maxillofacial Implants
Journal Journal of clinical medicine
Volume 8
Number 6
Pages / Article-Number 16
Abstract Polyetheretherketone (PEEK) is a prime candidate to replace metallic implants and prostheses in orthopedic, spine and cranio-maxillofacial surgeries. Fused-filament fabrication (FFF) is an economical and efficient three-dimensional (3D) printing method to fabricate PEEK implants. However, studies pertaining to the bioactivity of FFF 3D printed PEEK are still lacking. In this study, FFF 3D printed PEEK samples were fabricated and modified with polishing and grit-blasting (three alumina sizes: 50, 120, and 250 µm) to achieve varying levels of surface roughness. In vitro cellular response of a human osteosarcoma cell line (SAOS-2 osteoblasts, cell adhesion, metabolic activity, and proliferation) on different sample surfaces of untreated, polished, and grit-blasted PEEK were evaluated. The results revealed that the initial cell adhesion on different sample surfaces was similar. However, after 5 days the untreated FFF 3D printed PEEK surfaces exhibited a significant increase in cell metabolic activity and proliferation with a higher density of osteoblasts compared with the polished and grit-blasted groups (; p; < 0.05). Therefore, untreated FFF 3D printed PEEK with high surface roughness and optimal printing structures might have great potential as an appropriate alloplastic biomaterial for reconstructive cranio-maxillofacial surgeries.
Publisher Multidisciplinary Digital Publishing Institute
ISSN/ISBN 2077-0383
URL https://www.mdpi.com/2077-0383/8/6/771/htm
edoc-URL https://edoc.unibas.ch/71086/
Full Text on edoc No
Digital Object Identifier DOI 10.3390/jcm8060771
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/31159171
ISI-Number WOS:000475349300015
Document type (ISI) Article
 
   

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