Altered apoptosis and cell cycling of mast cells in bone marrow lesions of patients with systemic mastocytosis
JournalItem (Reviews, Editorials, Rezensionen, Urteilsanmerkungen etc. in einer wissenschaftlichen Zeitschrift)
 
ID 4507671
Author(s) Baldus, Stephan E; Zirbes, Thomas K; Thiele, Juergen; Eming, Sabine A; Henz, Beate M; Hartmann, Karin
Author(s) at UniBasel Hartmann, Karin
Year 2004
Title Altered apoptosis and cell cycling of mast cells in bone marrow lesions of patients with systemic mastocytosis
Journal Haematologica
Volume 89
Number 12
Pages 1525-1527
Mesh terms Adult; Aged; Apoptosis; Bone Marrow, pathology; Cell Cycle; Cyclin-Dependent Kinase Inhibitor p21, analysis; Female; Humans; In Situ Nick-End Labeling; Ki-67 Antigen, analysis; Male; Mast Cells, chemistry, pathology; Mastocytosis, Systemic, pathology; Middle Aged; Proto-Oncogene Proteins c-bcl-2, analysis; Tumor Suppressor Protein p53, analysis
Abstract

Enhanced expression of the apoptosis-preventing protein bcl-xL and the cell cycle-regulating protein p21 was observed in bone marrow infiltrates of systemic mastocytosis. Expression of bcl-2, Ki67, and p53 as well as ISEL apoptosis staining were comparable in patients with mastocytosis and in controls. An altered rate of apoptosis and cell cycling may contribute to accumulation of mast cells in mastocytosis.

ISSN/ISBN 1592-8721
Full Text on edoc
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/15590405
   

MCSS v5.8 PRO. 0.438 sec, queries - 0.000 sec ©Universität Basel  |  Impressum   |    
10/08/2020