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Altered apoptosis and cell cycling of mast cells in bone marrow lesions of patients with systemic mastocytosis
JournalItem (Reviews, Editorials, Rezensionen, Urteilsanmerkungen etc. in einer wissenschaftlichen Zeitschrift)
 
ID 4507671
Author(s) Baldus, Stephan E.; Zirbes, Thomas K.; Thiele, Juergen; Eming, Sabine A.; Henz, Beate M.; Hartmann, Karin
Author(s) at UniBasel Hartmann, Karin
Year 2004
Title Altered apoptosis and cell cycling of mast cells in bone marrow lesions of patients with systemic mastocytosis
Journal Haematologica
Volume 89
Number 12
Pages 1525-7
Mesh terms Adult; Aged; Apoptosis; Bone Marrow, pathology; Cell Cycle; Cyclin-Dependent Kinase Inhibitor p21, analysis; Female; Humans; In Situ Nick-End Labeling; Ki-67 Antigen, analysis; Male; Mast Cells, chemistry, pathology; Mastocytosis, Systemic, pathology; Middle Aged; Proto-Oncogene Proteins c-bcl-2, analysis; Tumor Suppressor Protein p53, analysis
Abstract Enhanced expression of the apoptosis-preventing protein bcl-xL and the cell cycle-regulating protein p21 was observed in bone marrow infiltrates of systemic mastocytosis. Expression of bcl-2, Ki67, and p53 as well as ISEL apoptosis staining were comparable in patients with mastocytosis and in controls. An altered rate of apoptosis and cell cycling may contribute to accumulation of mast cells in mastocytosis.
Publisher Ferrata Storti Foundation
ISSN/ISBN 0390-6078 ; 1592-8721
edoc-URL https://edoc.unibas.ch/70836/
Full Text on edoc No
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/15590405
Document type (ISI) Letter
 
   

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