A case of linear porokeratosis superimposed on disseminated superficial actinic porokeratosis
JournalItem (Reviews, Editorials, Rezensionen, Urteilsanmerkungen etc. in einer wissenschaftlichen Zeitschrift)
 
ID 4507619
Author(s) Löhrer, Rebecca; Neumann-Acikel, Aysegül; Eming, Rüdiger; Hartmann, Karin; Rasokat, Heinrich; Krieg, Thomas; Happle, Rudolf; Eming, Sabine
Author(s) at UniBasel Hartmann, Karin
Year 2010
Title A case of linear porokeratosis superimposed on disseminated superficial actinic porokeratosis
Journal Case Reports in Dermatology
Volume 2
Number 2
Pages 130-134
Abstract

We present a female patient with linear porokeratosis of her right arm since childhood. At the age of 67 years she additionally developed disseminated superficial actinic porokeratosis (DSAP) involving both lower legs. This uncommon coexistence of two different types of porokeratosis fulfils the clinical criteria of a type 2 segmental manifestation of an autosomal dominant skin disorder, being superimposed on the ordinary nonsegmental lesions and reflecting loss of heterozygosity that occurred at an early developmental stage. In DSAP molecular evidence of this concept is so far lacking, but such proof has already been provided in several other autosomal dominant skin disorders. Molecular analysis of cases of type 2 segmental involvement may help elucidate the genetic defect causing DSAP.

ISSN/ISBN 1662-6567
Full Text on edoc
Digital Object Identifier DOI 10.1159/000319708
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/21399730
   

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