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Although abundant in tumor tissue, mast cells have no effect on immunological micro-milieu or growth of HPV-induced or transplanted tumors
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 4507248
Author(s) Ghouse, Shanawaz Mohammed; Polikarpova, Anastasia; Muhandes, Lina; Dudeck, Jan; Tantcheva-Poór, Iliana; Hartmann, Karin; Lesche, Matthias; Dahl, Andreas; Eming, Sabine; Müller, Werner; Behrendt, Rayk; Roers, Axel
Author(s) at UniBasel Hartmann, Karin
Year 2018
Title Although abundant in tumor tissue, mast cells have no effect on immunological micro-milieu or growth of HPV-induced or transplanted tumors
Journal Cell Reports
Volume 22
Number 1
Pages / Article-Number 27-35
Mesh terms Animals; Cell Line; Cell Proliferation; Cell Transformation, Viral, immunology; Epithelial Cells, immunology, pathology, virology; Mast Cells, immunology, pathology; Mice; Mice, Transgenic; Neoplasm Transplantation; Neoplasms, Experimental, blood supply, immunology, pathology, virology; Neovascularization, Pathologic, immunology, pathology, virology; Papillomaviridae, immunology
Abstract High numbers of mast cells populate the stroma of many types of neoplasms, including human papilloma virus-induced benign and malignant tumors in man and mouse. Equipped with numerous pattern recognition receptors and capable of executing important pro-inflammatory responses, mast cells are considered innate sentinels that significantly impact tumor biology. Mast cells were reported to promote human papilloma virus (HPV)-induced epithelial hyperproliferation and neo-angiogenesis in an HPV-driven mouse model of skin cancer. We analyzed HPV-induced epithelial hyperplasia and squamous cell carcinoma formation, as well as growth of tumors inoculated into the dermis, in mice lacking skin mast cells. Unexpectedly, the absence of mast cells had no effect on HPV-induced epithelial growth or angiogenesis, on growth kinetics of inoculated tumors, or on the immunological tumor micro-milieu. Thus, the conspicuous recruitment of mast cells into tumor tissues cannot necessarily be equated with important mast cell functions in tumor growth.
Publisher CELL PRESS
ISSN/ISBN 2211-1247
edoc-URL https://edoc.unibas.ch/70746/
Full Text on edoc No
Digital Object Identifier DOI 10.1016/j.celrep.2017.12.010
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/29298428
ISI-Number WOS:000419131600004
Document type (ISI) Article
 
   

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