Evaluation of tools for annual capture of adherence to immunosuppressive medications after renal transplantation - a single-centre open prospective trial
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID
4501682
Author(s)
Gustavsen, Marte Theie; Midtvedt, Karsten; Lonning, Kjersti; Jacobsen, Thea; Varberg Reisaeter, Anna; De Geest, Sabina; Andersen, Marit Helen; Hartmann, Anders; Asberg, Anders
Author(s) at UniBasel
De Geest, Sabina M.
Year
2019
Title
Evaluation of tools for annual capture of adherence to immunosuppressive medications after renal transplantation - a single-centre open prospective trial
Journal
Transplant International
Volume
32
Number
6
Pages / Article-Number
614-625
Mesh terms
Adult; Aged; Biopsy; Cross-Sectional Studies; Data Collection, methods; Drug Administration Schedule; Female; Graft Rejection; Humans; Immunosuppressive Agents, administration & dosage; Kidney Failure, Chronic, surgery; Kidney Transplantation; Male; Medication Adherence, statistics & numerical data; Middle Aged; Norway; Prospective Studies; Registries; Risk Factors; Self Report; Surveys and Questionnaires; Transplant Recipients; Treatment Outcome
Abstract
Annual assessment of adherence would strengthen long-term outcome assessments from registry data. The objective of this study was to evaluate tools suitable for annual routine capture of adherence data in renal transplant recipients. A single-centre open prospective trial included 295 renal transplant recipients on tacrolimus. Two-thirds of the patients were included 4 weeks post-transplant, randomized 1:1 to intensive or single-point adherence assessment in the early phase and 1-year post-transplant. One-third were included 1-year post-transplant during a cross-sectional investigation. Adherence was assessed using multiple methods: The "BaselAssessment of Adherence to Immunosuppressive Medication Scale" (BAASIS© ) questionnaire was used to assess self-reported adherence. The treating clinician scored patient's adherence and tacrolimus trough-concentration variability was calculated. In the analyses, the data from the different tools were dichotomized (adherent/nonadherent). The BAASIS© overall response rate was over 80%. Intensive BAASIS© assessment early after transplantation increased the chance of capturing a nonadherence event, but did not influence the 1-year adherence prevalence. The adherence tools generally captured different populations. Combining the tools, the nonadherence prevalence at 1 year was 38%. The different tools identified to a large degree different patients as nonadherent. Combining these tools is feasible for annual capture of adherence status.© 2019 Steunstichting ESOT.
Publisher
Wiley
ISSN/ISBN
0934-0874 ; 1432-2277
URL
https://onlinelibrary.wiley.com/doi/epdf/10.1111/tri.13412
edoc-URL
https://edoc.unibas.ch/70474/
Full Text on edoc
No
Digital Object Identifier DOI
10.1111/tri.13412
PubMed ID
http://www.ncbi.nlm.nih.gov/pubmed/30770608
ISI-Number
WOS:000471898600008
Document type (ISI)
Clinical Trial, Journal Article
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