Aerosol immunisation for TB: matching route of vaccination to route of infection
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 4501632
Author(s) Manjaly Thomas, Zita-Rose; McShane, Helen
Author(s) at UniBasel Manjaly Thomas, Zita-Rose
Year 2015
Title Aerosol immunisation for TB: matching route of vaccination to route of infection
Journal Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume 109
Number 3
Pages / Article-Number 175-81
Mesh terms Adjuvants, Immunologic, administration & dosage; Administration, Inhalation; Aerosols; BCG Vaccine, administration & dosage; Humans; Immunization, methods; Tuberculosis, Pulmonary, immunology, prevention & control
Abstract TB remains a very significant global health burden. There is an urgent need for better tools for TB control, which include an effective vaccine. Bacillus Calmette-Guérin (BCG), the currently licensed vaccine, confers highly variable protection against pulmonary TB, the main source of TB transmission. Replacing BCG completely or boosting BCG with another vaccine are the two current strategies for TB vaccine development. Delivering a vaccine by aerosol represents a way to match the route of vaccination to the route of infection. This route of immunisation offers not only the scientific advantage of delivering the vaccine directly to the respiratory mucosa, but also practical and logistical advantages. This review summarises the state of current TB vaccine candidates in the pipeline, reviews current progress in aerosol administration of vaccines in general and evaluates the potential for TB vaccine candidates to be administered by the aerosol route.
Publisher OXFORD UNIV PRESS
ISSN/ISBN 0035-9203
edoc-URL https://edoc.unibas.ch/70453/
Full Text on edoc No
Digital Object Identifier DOI 10.1093/trstmh/tru206
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/25636950
ISI-Number WOS:000350981100004
Document type (ISI) Journal Article, Review
 
   

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