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Antiprotozoal germacranolide sesquiterpene lactones from Tanacetum sonbolii
Journal
Planta medica
Volume
85
Number
5
Pages / Article-Number
424-430
Mesh terms
Animals; Antiprotozoal Agents, pharmacology; Cell Line; Flowers, chemistry; Inhibitory Concentration 50; Lactones, pharmacology; Magnetic Resonance Spectroscopy; Mass Spectrometry; Myoblasts, drug effects; Plant Components, Aerial, chemistry; Rats; Sesquiterpenes, Germacrane, pharmacology; Tanacetum, chemistry; Trypanosoma brucei rhodesiense, drug effects
Abstract
A phytochemical investigation of extracts from flowers and aerial parts of; Tanacetum sonbolii; afforded 7 new germacranolide sesquiterpene lactones. The structures were established by a combination of 1- and 2-dimensional nuclear magnetic resonance spectroscopy, high-resolution mass spectrometry, and electronic circular dichroism. The; in vitro; antiprotozoal activity of the compounds against; Trypanosoma brucei rhodesiense; and cytotoxicity against rat myoblast (L6) cells were determined. Compounds 4: and 5: showed IC; 50; values of 5.1 and 10.2 µM and selectivity indices of 3.9 and 4.0, respectively.
