Ring Expanded Glycomimetic FimH Antagonists as Lead Compounds for anti-UTI Therapies
Third-party funded project
Project title Ring Expanded Glycomimetic FimH Antagonists as Lead Compounds for anti-UTI Therapies
Principal Investigator(s) Ernst, Beat
Organisation / Research unit Departement Pharmazeutische Wissenschaften / Molekulare Pharmazie (Ernst)
Project start 01.08.2018
Probable end 31.07.2020
Status Completed
Abstract
The application seeks to identify small molecule anti- adhesins for FimH that will antagonize the association of E.coli with cell surface glycoproteins - which is the first steps in the initiation and progression of urinary tract infections (UTI). If successful, this research may yield potentially new therapies for the treatment of UTI, and is thus highly significant.
Keywords Bacterial infection, urinary tract infection, septanoses
Financed by Foreign Governmental Research Agencies
   

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10/08/2020