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A comprehensive framework for physiologically based pharmacokinetic modelling in Matlab.
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 4499453
Author(s) Stader, Felix; Penny, Melissa A.; Siccardi, Marco; Marzolini, Catia
Author(s) at UniBasel Marzolini, Catia
Stader, Felix
Penny, Melissa
Year 2019
Title A comprehensive framework for physiologically based pharmacokinetic modelling in Matlab.
Journal CPT: Pharmacometrics and Systems Pharmacology
Volume 8
Number 7
Pages / Article-Number 444-459
Keywords PBPK; Matlab®; modelling; pharmacokinetics
Abstract Physiologically based pharmacokinetic (PBPK) models are useful tools to predict clinical scenarios for special populations for whom there are high hurdles to conduct clinical trials such as children or the elderly. However, coding of a PBPK model in a mathematical programming language can be challenging. This tutorial illustrates how to build a whole-body PBPK model in Matlab; ®; to answer specific pharmacological questions involving drug disposition, and magnitudes of drug-drug interactions in different patient populations.
Publisher Wiley
ISSN/ISBN 2163-8306
edoc-URL https://edoc.unibas.ch/69629/
Full Text on edoc Available
Digital Object Identifier DOI 10.1002/psp4.12399
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/30779335
ISI-Number WOS:000477019400004
Document type (ISI) Article
 
   

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