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Role of distinct type-IV-secretion systems and secreted effector sets in host adaptation by pathogenic Bartonella species
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 4498876
Author(s) Wagner, Alexander; Dehio, Christoph
Author(s) at UniBasel Dehio, Christoph
Wagner, Alexander
Year 2019
Title Role of distinct type-IV-secretion systems and secreted effector sets in host adaptation by pathogenic Bartonella species
Journal Cellular microbiology
Volume 21
Number 3
Pages / Article-Number e13004
Keywords Bartonella; Bep effector proteins; Trw; VirB/VirD4; host adaptation; type-IV-secretion systems
Abstract The α-proteobacterial genus Bartonella comprises a large number of facultative intracellular pathogens that share a common lifestyle hallmarked by hemotrophic infection and arthropod transmission. Speciation in the four deep-branching lineages (L1-L4) occurred by host adaptation facilitating the establishment of long lasting bacteraemia in specific mammalian reservoir host(s). Two distinct type-IV-secretion systems (T4SSs) acquired horizontally by different Bartonella lineages mediate essential host interactions during infection and represent key innovations for host adaptation. The Trw-T4SS confined to the species-rich L4 mediates host-specific erythrocyte infection and likely has functionally replaced flagella as ancestral virulence factors implicated in erythrocyte colonisation by bartonellae of the other lineages. The VirB/VirD4-T4SS translocates Bartonella effector proteins (Bep) into various host cell types to modulate diverse cellular and innate immune functions involved in systemic spreading of bacteria following intradermal inoculation. Independent acquisition of the virB/virD4/bep locus by L1, L3, and L4 was likely driven by arthropod vectors associated with intradermal inoculation of bacteria rather than facilitating direct access to blood. Subsequently, adaptation to colonise specific niches in the new host has shaped the evolution of complex species-specific Bep repertoires. This diversification of the virulence factor repertoire of Bartonella spp. represents a remarkable example for parallel evolution of host adaptation.
Publisher John Wiley & Sons Ltd.
ISSN/ISBN 1462-5814 ; 1462-5822
edoc-URL https://edoc.unibas.ch/69452/
Full Text on edoc Available
Digital Object Identifier DOI 10.1111/cmi.13004
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/30644157
ISI-Number WOS:000458950700014
Document type (ISI) Journal Article, Review
 
   

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