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Association of long-term exposure to traffic-related PM; 10; with heart rate variability and heart rate dynamics in healthy subjects
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 4498867
Author(s) Meier-Girard, Delphine; Delgado-Eckert, Edgar; Schaffner, Emmanuel; Schindler, Christian; Künzli, Nino; Adam, Martin; Pichot, Vincent; Kronenberg, Florian; Imboden, Medea; Frey, Urs; Probst-Hensch, Nicole
Author(s) at UniBasel Schaffner, Emmanuel
Schindler, Christian
Künzli, Nino
Imboden, Medea
Probst Hensch, Nicole
Frey, Urs Peter
Delgado-Eckert, Edgar
Year 2019
Title Association of long-term exposure to traffic-related PM; 10; with heart rate variability and heart rate dynamics in healthy subjects
Journal Environment international
Volume 125
Pages / Article-Number 107-116
Keywords Air pollution; Heart rate variability; Nonlinear dynamics; Particulate matter; Vehicle emissions
Mesh terms Aged; Air Pollutants, analysis, toxicity; Cardiovascular Diseases, chemically induced; Cohort Studies; Female; Follow-Up Studies; Glutathione Transferase, genetics; Healthy Volunteers; Heart Rate, drug effects; Humans; Linear Models; Male; Middle Aged; Obesity, chemically induced; Particulate Matter, analysis, toxicity; Smoking
Abstract Epidemiological evidence on the influence of long-term exposure to traffic-related particulate matter (TPM; 10; ) on heart rate variability (HRV) is weak.; To evaluate the association of long-term exposure (10 years) with TPM; 10; on the regulation of the autonomic cardiovascular system and heart rate dynamics (HRD) in an aging general population, as well as potential modifying effects by the a priori selected factors sex, smoking status, obesity, and gene variation in selected glutathione S-transferases (GSTs).; We analyzed data from 1593 SAPALDIA cohort participants aged ≥ 50 years. For each participant, various HRV and HRD parameters were derived from 24-hour electrocardiogram recordings. Each parameter obtained was then used as the outcome variable in multivariable mixed linear regression models in order to evaluate the association with TPM; 10; . Potential modifying effects were assessed using interaction terms.; No association between long-term exposure to TPM; 10; and HRV/HRD was observed in the entire study population. However, HRD changes were found in subjects without cardiovascular morbidity and both HRD and HRV changes in non-obese subjects without cardiovascular morbidity. Subjects without cardiovascular morbidity with homozygous GSTM1 gene deletion appeared to be more susceptible to the effects of TPM; 10; .; This study suggests that long-term exposure to TPM; 10; triggers adverse changes in the regulation of the cardiovascular system. These adverse effects were more visible in the subjects without cardiovascular disease, in whom the overall relationship between TPM; 10; and HRV/HRD could not be masked by underlying morbidities and the potential counteracting effects of related drug treatments.
Publisher Elsevier
ISSN/ISBN 0160-4120
edoc-URL https://edoc.unibas.ch/69451/
Full Text on edoc Available
Digital Object Identifier DOI 10.1016/j.envint.2019.01.031
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/30716571
 
   

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