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A Brain-wide Circuit Model of Heat-Evoked Swimming Behavior in Larval Zebrafish
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 4497577
Author(s) Haesemeyer, Martin; Robson, Drew N.; Li, Jennifer M.; Schier, Alexander F.; Engert, Florian
Author(s) at UniBasel Schier, Alexander
Year 2018
Title A Brain-wide Circuit Model of Heat-Evoked Swimming Behavior in Larval Zebrafish
Journal Neuron
Volume 98
Number 4
Pages / Article-Number 817-+
Abstract Thermosensation provides crucial information, but how temperature representation is transformed from sensation to behavior is poorly understood. Here, we report a preparation that allows control of heat delivery to zebrafish larvae while monitoring motor output and imaging whole-brain calcium signals, thereby uncovering algorithmic and computational rules that couple dynamics of heat modulation, neural activity and swimming behavior. This approach identifies a critical step in the transformation of temperature representation between the sensory trigeminal ganglia and the hindbrain: A simple sustained trigeminal stimulus representation is transformed into a representation of absolute temperature as well as temperature changes in the hindbrain that explains the observed motor output. An activity constrained dynamic circuit model captures the most prominent aspects of these sensori-motor transformations and predicts both behavior and neural activity in response to novel heat stimuli. These findings provide the first algorithmic description of heat processing from sensory input to behavioral output.
Publisher CELL PRESS
ISSN/ISBN 1097-4199
edoc-URL https://edoc.unibas.ch/69127/
Full Text on edoc No
Digital Object Identifier DOI 10.1016/j.neuron.2018.04.013
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/29731253
ISI-Number WOS:000432474200017
Document type (ISI) Article
 
   

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