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Pharmacogenotyping in pharmaceutical care
Project funded by own resources
Project title Pharmacogenotyping in pharmaceutical care
Principal Investigator(s) Hersberger, Kurt
Co-Investigator(s) Jeiziner, Chiara
Meyer zu Schwabedissen, Henriette
Suter-Zimmermann, Katja
Lampert, Markus Leopold
Stšuble, Cťline
Organisation / Research unit Departement Pharmazeutische Wissenschaften / Pharmaceutical Care (Hersberger)
Project start 01.08.2018
Probable end 31.07.2022
Status Completed
Abstract

With the developing knowledge on genetic variants influencing pharmacokinetics and/or pharmacodynamics of frequently applied drugs, multiple providers are now offering PGx assessment using DNA isolated from buccal swaps. In an observational study, we intend to collect patient cases in community and hospital pharmacies, where pharmacogenotyping is applied. Stratipharm (www.stratipharm.de) is a commercial service offering pharmacogenotyping in combination with sophisticated evidence-based interpretation of the genotype. The test system covers almost 100 genetic variants corresponding to 30 genes of pharmacogenetic relevance.

In our case series [ClinicalTrials.gov identifier: NCT04154553; EKNZ Identifier: 2019-01452] over 3 years, the primary objective is the compilation of case reports, where pharmacogenetic testing is applied to determine the hereditable component of the patient’s susceptibility to experience therapy failure and/or adverse drug reactions. The patient receives the results of the pharmacogenotyping in form of a written recommendation to their prescribing physician. The experience with the compiled cases will be basis for the development of a reliable standard operating procedure for pharmacogenetic testing in the community as well as the hospital pharmacy. Therefore, the setup of a training for pharmacists as well as an interprofessional network is crucial.

Financed by University funds
Other funds

Published results ()

  ID Autor(en) Titel ISSN / ISBN Erschienen in Art der Publikation
4611136  Jeiziner, C.; Suter, K.; Wernli, U.; Barbarino, J. M.; Gong, L.; Whirl-Carrillo, M.; Klein, T. E.; Szucs, T. D.; Hersberger, K. E.; Meyer Zu Schwabedissen, H. E.  Pharmacogenetic information in Swiss drug labels - a systematic analysis  1470-269X ; 1473-1150  Pharmacogenomics Journal  Publication: JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) 
4617314  Jeiziner, Chiara; Stšuble, Cťline K; Lampert, Markus L; Hersberger, Kurt E; Meyer Zu Schwabedissen, Henriette E  Enriching Medication Review with a Pharmacogenetic Profile - A Case of Tamoxifen Adverse Drug Reactions.  1178-7066  Pharmacogenomics and personalized medicine  JournalItem (Kommentare, Editorials, Rezensionen, Urteilsanmerk., etc. in einer wissensch. Zeitschr. 
   

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11/12/2023