Evolutionary and energetic landscapes of enzyme catalyzed oxidative sulfur transfers
Third-party funded project
Project title Evolutionary and energetic landscapes of enzyme catalyzed oxidative sulfur transfers
Principal Investigator(s) Seebeck, Florian Peter
Project Members Lim, David
Nalivaiko, Egor
Vasseur, Camille Michelle
Organisation / Research unit Departement Chemie / Molecular Bionics (Seebeck),
Departement Chemie / Organische Chemie (Gademann)
Project start 01.09.2019
Probable end 31.08.2023
Status Active
Abstract

Sulfur containing metabolites are ubiquitous and important factors in all life forms. Deciphering their physiological functions, their chemical reactivity and their biosynthetic origins has proven a productive avenue to identify causes and remedies of human disease, to understand microbial contributions and reactions to climate change, and to recognize fundamental patterns of molecular evolutions. The discovery and description of sulfur-related biochemistry also provides important impulses for biotechnological innovation. In this very active field we plan to pursue the following key aims: 1) Mechanistic characterization of enzymes that mediate oxidative carbon-sulfur transfers. 2) Prospecting the landscape of EGT biosynthesis. 3) Description of a novel class of sulfur metabolites. 4) Characterisation of the catalytic mechanism of the formylglycine generating enzyme.

Keywords natural products; ergothioneine; catalysis; metalloenzyme; formylglycine; oxygen activation; enzymology; copper enzymes; iron enzymes; protein evolution
Financed by Swiss National Science Foundation (SNSF)
   

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10/08/2020