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A Combined Mathematical Model Linking the Formation of Amorphous Solid Dispersions with Hot-Melt-Extrusion Process Parameters
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 4485847
Author(s) Schittny, A.; Ogawa, H.; Huwyler, J.; Puchkov, M.
Author(s) at UniBasel Huwyler, Jörg
Schittny, Andreas
Puchkov, Maxim
Year 2018
Title A Combined Mathematical Model Linking the Formation of Amorphous Solid Dispersions with Hot-Melt-Extrusion Process Parameters
Journal European Journal of Pharmaceutics and Biopharmaceutics
Volume 132
Pages / Article-Number 127-145
Abstract Hot-melt extrusion allows for the continuous production of amorphous solid dispersions, which are used to enhance bioavailability of poorly soluble drugs in pharmaceutical drug delivery. To facilitate formulation and extrusion process development, we propose a mathematical model describing the formation of amorphous solid dispersions in the context of this process. The model is based on the calculation of two key process values: 1) time to dissolution of solid drug particles in molten polymer during extrusion and 2) mean residence of material in the extruder. We suggest that their linking allows for rational process design. Experimental data support the validity of our model for both key process values as well as the overall process. This modeling approach allows for fast and cost-effective formulation and extrusion process development as well as feasibility estimations in early stages of drug development.
Publisher Elsevier
ISSN/ISBN 0939-6411 ; 1873-3441
edoc-URL https://edoc.unibas.ch/65616/
Full Text on edoc No
Digital Object Identifier DOI 10.1016/j.ejpb.2018.09.011
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/30240820
ISI-Number MEDLINE:30240820
Document type (ISI) Journal Article
 
   

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