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A three-generation study on the association of tobacco smoking with asthma
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID 4485734
Author(s) Accordini, Simone; Calciano, Lucia; Johannessen, Ane; Portas, Laura; Benediktsdóttir, Bryndis; Bertelsen, Randi Jacobsen; Brĺbäck, Lennart; Carsin, Anne-Elie; Dharmage, Shyamali C.; Dratva, Julia; Forsberg, Bertil; Gomez Real, Francisco; Heinrich, Joachim; Holloway, John W.; Holm, Mathias; Janson, Christer; Jögi, Rain; Leynaert, Bénédicte; Malinovschi, Andrei; Marcon, Alessandro; Martínez-Moratalla Rovira, Jesús; Raherison, Chantal; Sánchez-Ramos, José Luis; Schlünssen, Vivi; Bono, Roberto; Corsico, Angelo G.; Demoly, Pascal; Dorado Arenas, Sandra; Nowak, Dennis; Pin, Isabelle; Weyler, Joost; Jarvis, Deborah; Svanes, Cecilie; Ageing Lungs in European Cohorts Study,
Author(s) at UniBasel Dratva, Julia
Year 2018
Title A three-generation study on the association of tobacco smoking with asthma
Journal International journal of epidemiology
Volume 47
Number 4
Pages / Article-Number 1106-1117
Abstract Mothers' smoking during pregnancy increases asthma risk in their offspring. There is some evidence that grandmothers' smoking may have a similar effect, and biological plausibility that fathers' smoking during adolescence may influence offspring's health through transmittable epigenetic changes in sperm precursor cells. We evaluated the three-generation associations of tobacco smoking with asthma.; Between 2010 and 2013, at the European Community Respiratory Health Survey III clinical interview, 2233 mothers and 1964 fathers from 26 centres reported whether their offspring (aged ≤51 years) had ever had asthma and whether it had coexisted with nasal allergies or not. Mothers and fathers also provided information on their parents' (grandparents) and their own asthma, education and smoking history. Multilevel mediation models within a multicentre three-generation framework were fitted separately within the maternal (4666 offspring) and paternal (4192 offspring) lines.; Fathers' smoking before they were 15 [relative risk ratio (RRR) = 1.43, 95% confidence interval (CI): 1.01-2.01] and mothers' smoking during pregnancy (RRR = 1.27, 95% CI: 1.01-1.59) were associated with asthma without nasal allergies in their offspring. Grandmothers' smoking during pregnancy was associated with asthma in their daughters [odds ratio (OR) = 1.55, 95% CI: 1.17-2.06] and with asthma with nasal allergies in their grandchildren within the maternal line (RRR = 1.25, 95% CI: 1.02-1.55).; Fathers' smoking during early adolescence and grandmothers' and mothers' smoking during pregnancy may independently increase asthma risk in offspring. Thus, risk factors for asthma should be sought in both parents and before conception.; European Union (Horizon 2020, GA-633212).
Publisher Oxford University Press
ISSN/ISBN 0300-5771
Full Text on edoc Available
Digital Object Identifier DOI 10.1093/ije/dyy031
PubMed ID
ISI-Number WOS:000444559900020
Document type (ISI) Article

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