An ER surface retrieval pathway safeguards the import of mitochondrial membrane proteins in yeast
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 4485180
Author(s) Hansen, Katja G.; Aviram, Naama; Laborenz, Janina; Bibi, Chen; Meyer, Maren; Spang, Anne; Schuldiner, Maya; Herrmann, Johannes M.
Author(s) at UniBasel Spang, Anne
Year 2018
Year: comment 2018
Title An ER surface retrieval pathway safeguards the import of mitochondrial membrane proteins in yeast
Journal Science
Volume 361
Number 6407
Pages / Article-Number 1118-+
Abstract The majority of organellar proteins are translated on cytosolic ribosomes and must be sorted correctly to function.Targeting routes have been identified for organelles such as peroxisomes and the endoplasmic reticulum (ER). However, little is known about the initial steps of targeting of mitochondrial proteins. In this study, we used a genome-wide screen in yeast and identified factors critical for the intracellular sorting of themitochondrial innermembrane protein Oxa1.The screen uncovered an unexpected path, termed ER-SURF, for targeting ofmitochondrialmembrane proteins.This pathway retrieves mitochondrial proteins from the ER surface and reroutes them to mitochondria with the aid of the ER-localized chaperone Djp1. Hence, cells use the expanse of the ERsurfaces as a fail-safe tomaximize productive mitochondrial protein targeting.
Publisher American Association for the Advancement of Science
ISSN/ISBN 0036-8075 ; 1095-9203
edoc-URL https://edoc.unibas.ch/65451/
Full Text on edoc Available
Digital Object Identifier DOI 10.1126/science.aar8174
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/14.09.2018
ISI-Number WOS:000444513300042
Document type (ISI) Article
 
   

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