Analysis of interventions against the liver fluke, Opisthorchis viverrini
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 4482821
Author(s) Bürli, Christine; Harbrecht, Helmut; Odermatt, Peter; Sayasone, Somphou; Chitnis, Nakul
Author(s) at UniBasel Harbrecht, Helmut
Chitnis, Nakul
Odermatt, Peter
Sayasone, Somphou
Bürli, Christine
Year 2018
Title Analysis of interventions against the liver fluke, Opisthorchis viverrini
Journal Mathematical biosciences : an international journal
Volume 303
Pages / Article-Number 115-125
Keywords Opisthorchis viverrini, mathematical modelling, simulation, optimal control, intervention
Abstract We adapt a population-based model of Opisthorchis viverrini transmission dynamics to determine the effectiveness of three different interventions. The model includes the definitive hosts, humans; the reservoir hosts, dogs and cats; and the intermediate hosts, snails and fish. We consider the interventions: education campaigns to reduce the consumption of raw or undercooked fish, improved sanitation and treatment through mass drug administration. We fit model parameters to a data set from two islands in southern Lao PDR. We calculate the control reproduction number, simulate different scenarios and optimise the interventions with optimal control. We look at the potential of the interventions to eliminate transmission within 20 years. The model shows that education and improved sanitation need a very high coverage to fulfil the goal of elimination, whereas annual drug distribution at medium coverage is sufficient. The best solution is a combination of drug distribution at a medium level of coverage and as high as possible coverage of education and improved sanitation.
Publisher American Elsevier
ISSN/ISBN 0025-5564
edoc-URL https://edoc.unibas.ch/65089/
Full Text on edoc Available
Digital Object Identifier DOI 10.1016/j.mbs.2018.06.008
ISI-Number WOS:000442710200010
Document type (ISI) Article
 
   

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