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The hepcidin-ferroportin axis controls the iron content of Salmonella-containing vacuoles in macrophages
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 4482694
Author(s) Lim, Daejin; Kim, Kwang Soo; Jeong, Jae-Ho; Marques, Oriana; Kim, Hyun-Ju; Song, Miryoung; Lee, Tae-Hoon; Kim, Jae Il; Choi, Hueng-Sik; Min, Jung-Joon; Bumann, Dirk; Muckenthaler, Martina U.; Choy, Hyon E.
Author(s) at UniBasel Bumann, Dirk
Year 2018
Title The hepcidin-ferroportin axis controls the iron content of Salmonella-containing vacuoles in macrophages
Journal Nature communications
Volume 9
Number 1
Pages / Article-Number 2091
Abstract Macrophages release iron into the bloodstream via a membrane-bound iron export protein, ferroportin (FPN). The hepatic iron-regulatory hormone hepcidin controls FPN internalization and degradation in response to bacterial infection. Salmonella typhimurium can invade macrophages and proliferate in the Salmonella-containing vacuole (SCV). Hepcidin is reported to increase the mortality of Salmonella-infected animals by increasing the bacterial load in macrophages. Here we assess the iron levels and find that hepcidin increases iron content in the cytosol but decreases it in the SCV through FPN on the SCV membrane. Loss-of-FPN from the SCV via the action of hepcidin impairs the generation of bactericidal reactive oxygen species (ROS) as the iron content decreases. We conclude that FPN is required to provide sufficient iron to the SCV, where iron serves as a cofactor for the generation of antimicrobial ROS rather than as a nutrient for Salmonella.
Publisher NATURE PUBLISHING GROUP
ISSN/ISBN 2041-1723
edoc-URL https://edoc.unibas.ch/65079/
Full Text on edoc No
Digital Object Identifier DOI 10.1038/s41467-018-04446-8
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/29844422
ISI-Number WOS:000433297900002
Document type (ISI) Article
 
   

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29/03/2024