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Acute Effects of Methylphenidate, Modafinil, and MDMA on Negative Emotion Processing
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 4482301
Author(s) Schmidt, André; Müller, Felix; Dolder, Patrick C.; Schmid, Yasmin; Zanchi, Davide; Egloff, Laura; Liechti, Matthias E.; Borgwardt, Stefan
Author(s) at UniBasel Schmidt, André
Liechti, Matthias Emanuel
Year 2018
Title Acute Effects of Methylphenidate, Modafinil, and MDMA on Negative Emotion Processing
Journal The international journal of neuropsychopharmacology
Volume 21
Number 4
Pages / Article-Number 345-354
Abstract Stimulants such as methylphenidate and modafinil are frequently used as cognitive enhancers in healthy people, whereas 3,4-methylenedioxymethamphetamine (ecstasy) is proposed to enhance mood and empathy in healthy subjects. However, comparative data on the effects of methylphenidate and modafinil on negative emotions in healthy subjects have been partially missing. The aim of this study was to compare the acute effects of methylphenidate and modafinil on the neural correlates of fearful face processing using 3,4-methylenedioxymethamphetamine as a positive control.; Using a double-blind, within-subject, placebo-controlled, cross-over design, 60 mg methylphenidate, 600 mg modafinil, and 125 mg 3,4-methylenedioxymethamphetamine were administrated to 22 healthy subjects while performing an event-related fMRI task to assess brain activation in response to fearful faces. Negative mood states were assessed with the State-Trait Anxiety Inventory and subjective ratings.; Relative to placebo, modafinil, but not methylphenidate or 3,4-methylenedioxymethamphetamine, increased brain activation within a limbic-cortical-striatal-pallidal-thalamic circuit during fearful face processing. Modafinil but not methylphenidate also increased amygdala responses to fearful faces compared with 3,4-methylenedioxymethamphetamine. Furthermore, activation in the middle and inferior frontal gyrus in response to fearful faces correlated positively with subjective feelings of fearfulness and depressiveness after modafinil administration.; Despite the cognitive enhancement effects of 600 mg modafinil in healthy people, potential adverse effects on emotion processing should be considered.
Publisher Oxford University Press
ISSN/ISBN 1461-1457 ; 1469-5111
URL https://academic.oup.com/ijnp/article/21/4/345/4675251
edoc-URL https://edoc.unibas.ch/65005/
Full Text on edoc Available
Digital Object Identifier DOI 10.1093/ijnp/pyx112
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/29206921
ISI-Number WOS:000432292100005
Document type (ISI) Journal Article
 
   

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