Data Entry: Please note that the research database will be replaced by UNIverse by the end of October 2023. Please enter your data into the system https://universe-intern.unibas.ch. Thanks

Login for users with Unibas email account...

Login for registered users without Unibas email account...

 
Is there a gender-specific association between asthma and carotid intima media thickness in Swiss adolescents?
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 4480628
Author(s) Dratva, Julia; Caviezel, Seraina; Schaffner, Emmanuel; Stolz, Daiana; Rothe, Thomas; Kuenzli, Nino; Schmidt-Trucksäss, Arno; Zemp, Elisabeth; Probst-Hensch, Nicole
Author(s) at UniBasel Dratva, Julia
Schaffner, Emmanuel
Künzli, Nino
Zemp Stutz, Elisabeth
Probst Hensch, Nicole
Schmidt-Trucksäss, Arno
Year 2018
Title Is there a gender-specific association between asthma and carotid intima media thickness in Swiss adolescents?
Journal European Journal of Pediatrics
Volume 177
Number 5
Pages / Article-Number 699-707
Abstract Respiratory diseases are associated with increased cardiovascular risk in adults, but little is known on the early impact on the vasculature in youth. The SAPALDIA Youth study, the offspring study of the Swiss Study on Air Pollution and Lung and Heart Disease In Adults (SAPALDIA), investigated the association between physician-diagnosed asthma status and common carotid artery intima media thickness (CIMT). Offspring underwent standardized clinical protocols and provided information on early life factors, health, and lifestyle. The association between per subject averages of CIMT and asthma was estimated using mixed linear regression analyses adjusting for main confounders, testing for interaction with gender and age. Of 257 offspring (mean age 15 years, 53% female), 11.5% reported doctor-diagnosed asthma (male 17%, female 7%). Mean CIMT was significantly different by gender (male 0.53 mm (± 0.045), female 0.50 mm (± 0.048); p < 0.001). Interaction was highly significant by gender (p = 0.001) with significantly increased CIMT in asthmatic vs. non-asthmatics boys (difference 0.023 mm, 95% CI 0.003; 0.043), as compared to girls.; Our study suggests an increased risk for early vascular change in adolescent asthmatic boys. Whereas the small number of girls limits the interpretation, the result necessitates further research into sex-specific atherosclerotic burden related to respiratory health in adolescence. What is Known: • Evidence points to a significant impact of adult respiratory disease on cardiovascular health indicators as well as on endpoints. • Inflammation is a key pathway in vascular change across the life course. What is New: • We observe an adverse association between physician-diagnosed asthma and carotid intima media thickness in adolescent boys. • Albeit a limited number of asthmatic girls, we hypothesize the gender typical timing of asthma or a higher male cardiovascular vulnerability as possible explanations for the gender-specific results.
Publisher Springer
ISSN/ISBN 0340-6199 ; 1432-1076
edoc-URL https://edoc.unibas.ch/64661/
Full Text on edoc Restricted
Digital Object Identifier DOI 10.1007/s00431-018-3107-0
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/29411143
ISI-Number WOS:000430003800009
Document type (ISI) Article
 
   

MCSS v5.8 PRO. 0.332 sec, queries - 0.000 sec ©Universität Basel  |  Impressum   |    
29/03/2024