A Longitudinal Item Response Theory Model to Characterize Cognition Over Time in Elderly Subjects
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 4479592
Author(s) Vandemeulebroecke, Marc; Bornkamp, Björn; Krahnke, Tillmann; Mielke, Johanna; Monsch, Andreas; Quarg, Peter
Author(s) at UniBasel Monsch, Andreas U.
Year 2017
Title A Longitudinal Item Response Theory Model to Characterize Cognition Over Time in Elderly Subjects
Journal CPT: Pharmacometrics and Systems Pharmacology
Volume 6
Number 9
Pages / Article-Number 635-641
Abstract For drug development in neurodegenerative diseases such as Alzheimer's disease, it is important to understand which cognitive domains carry the most information on the earliest signs of cognitive decline, and which subject characteristics are associated with a faster decline. A longitudinal Item Response Theory (IRT) model was developed for the Basel Study on the Elderly, in which the Consortium to Establish a Registry for Alzheimer's Disease - Neuropsychological Assessment Battery (with additions) and the California Verbal Learning Test were measured on 1,750 elderly subjects for up to 13.9 years. The model jointly captured the multifaceted nature of cognition and its longitudinal trajectory. The word list learning and delayed recall tasks carried the most information. Greater age at baseline, fewer years of education, and positive APOEɛ4 carrier status were associated with a faster cognitive decline. Longitudinal IRT modeling is a powerful approach for progressive diseases with multifaceted endpoints.
Publisher WILEY
ISSN/ISBN 2163-8306
URL https://doi.org/10.1002/psp4.12219
edoc-URL https://edoc.unibas.ch/66746/
Full Text on edoc No
Digital Object Identifier DOI 10.1002/psp4.12219
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/28643388
ISI-Number WOS:000411726900008
Document type (ISI) Article
 
   

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