Clinical performance of self-assembling peptide {P11-4} in treatment of initial proximal carious lesions, a practice based case series
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 4478993
Author(s) Schlee, Markus; Schad, Till; Koch, Jan H.; Cattin, Philippe C.; Rathe, Florian
Author(s) at UniBasel Cattin, Philippe Claude
Year 2017
Title Clinical performance of self-assembling peptide {P11-4} in treatment of initial proximal carious lesions, a practice based case series
Journal Journal of Investigative and Clinical Dentistry
Volume 9
Number 1
Pages / Article-Number 1
Mesh terms Adolescent; Adult; Aged; Biomimetic Materials, therapeutic use; Dental Caries, drug therapy; Female; Humans; Male; Materials Testing; Middle Aged; Oligopeptides, therapeutic use; Prospective Studies; Radiography, Dental, Digital; Surface Properties; Tooth Remineralization; Young Adult
Abstract AIM:The aim of the present study was to investigate the clinical performance of self-assembling peptide P11 -4 on non-cavitated initial proximal carious lesions 12 months after treatment. METHODS:Twenty-six patients, aged between 18 and 65 years, with 35 carious lesions were included in this practice-based, uncontrolled, prospective case series. The opacity and size of the proximal lesions were evaluated visually at baseline and at day 360 using standardized single-tooth or bite-wing and digital-subtraction radiography. Pairwise evaluation of images was carried out in a randomized and blinded manner with respect to the time point. RESULTS: Twelve months after treatment of the proximal carious lesions, the visual evaluation showed a predominant shift toward regression of the initial lesions. Radiographic assessment yielded regression of the caries in 17 of 28 cases; four of 28 were regarded as unchanged, and seven of 28 lesions showed progression of the carious lesion. Combined assessment of clinical radiographs and digital subtraction radiographs confirmed the radiographic assessment, with 20 of 28 lesions showing total or partial regression, four unchanged, and four progressing. CONCLUSION:Radiographic and digital subtraction analyses suggest that initial proximal carious lesions can regress after treatment with P11 -4, but additional factors might influence the overall treatment outcome.
Publisher WILEY
ISSN/ISBN 0093-8769
edoc-URL https://edoc.unibas.ch/63995/
Full Text on edoc No
Digital Object Identifier DOI 10.1111/jicd.12286
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/28868637
ISI-Number WOS:000424272100023
Document type (ISI) Journal Article, Randomized Controlled Trial
 
   

MCSS v5.8 PRO. 0.443 sec, queries - 0.000 sec ©Universität Basel  |  Impressum   |    
03/12/2020