We investigate the impact of reduced renal mass (unilateral nephrectomy) on the homeostasis of L-arginine (Prof. F. Verrey, University of Zürich), glucocorticoids (Prof. A. Odermatt, University of Basel), bile acids and drugs (Prof. G.A. Kullak-Ublick, University of Zürich) using cell and rodent models and taking advantage of complementary expertises in physiology (F. Verrey), toxicology (A. Odermatt), and clinical pharmacology (G.A. Kullak-Ublick). These studies will yield important knowledge about the effect of reduced kidney mass on the renal and hepatic metabolism of three classes of organic molecules known to impact on body metabolism and blood pressure control.

Furthermore, we investigate the impact of reduced renal mass (unilateral nephrectomy) on main metabolic functions of the body taking advantage of established rodent models and the complementary expertise of basic (Prof. J. P. Montani, University of Fribourg, Prof. A. Odermatt) and clinical (Dr. D. Konrad, University of Zürich) scientists. We test the hypothesis that a loss of renal tissue may worsen or even induce a metabolic syndrome. Together with the results from project 1, the studies may provide novel insights into a yet not well understood cross-talk of the kidney with other metabolically active organs. The studies will also contribute to the long-term risk assessment of unilateral nephrectomy.