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Brainstem Circuits Controlling Movement
Third-party funded project
Project title Brainstem Circuits Controlling Movement
Principal Investigator(s) Arber, Silvia
Project Members Gunapala, Keith
Neves Ferreira Pinto, Manuel Joao
Yang, Wuzhou
Schina, Riccardo
Sridharan, Madhav
Thornton, Staci
Costa Afonso, Ana Rita
Organisation / Research unit Departement Biozentrum / Cell Biology (Arber),
Friedrich Miescher Institut FMI
Project Website https://p3.snf.ch/project-179403
Project start 01.04.2018
Probable end 31.03.2022
Status Completed
Abstract

One of the most important tasks of the nervous system is the generation of specific forms of movement as behavioral output, allowing animals or humans to interact with their surroundings appropriately according to motor plans and/or in response to influence from the environment. The motor system is broadly distributed across the nervous system, including areas close to actual motor program execution in the spinal cord, all the way up to regions of the nervous system involved in decision making and planning of motor acts. The brainstem is a key intermediary structure between higher motor centers and spinal circuits, and we have hypothesized that distinct subpopulations of brainstem neurons mediate selective motor programs. The goal of this work is to unravel key defining features of brainstem neurons involved in the regulation of diverse forms of movement, and to understand how a particular behavior is chosen over others. Our project will contribute to uncovering organizational principles of neuronal circuits in the motor output system of mice, as well as the contributions of these circuits to behavioral function.

Keywords Motor control; Neuronal circuits; Mouse genetics
Financed by Swiss National Science Foundation (SNSF)

Published results ()

  ID Autor(en) Titel ISSN / ISBN Erschienen in Art der Publikation
4500774  Takeoka, Aya; Arber, Silvia  Functional Local Proprioceptive Feedback Circuits Initiate and Maintain Locomotor Recovery after Spinal Cord Injury  2211-1247  Cell reports  Publication: JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) 
2690387  Pecho-Vrieseling, Eline; Rieker, Claus; Fuchs, Sascha; Bleckmann, Dorothee; Esposito, Maria Soledad; Botta, Paolo; Goldstein, Chris; Bernhard, Mario; Galimberti, Ivan; Müller, Matthias; Lüthi, Andreas; Arber, Silvia; Bouwmeester, Tewis; van der Putten, Herman; Di Giorgio, Francesco Paolo  Transneuronal propagation of mutant huntingtin contributes to non-cell autonomous pathology in neurons  1097-6256  Nature neuroscience  Publication: JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) 
4483836  Pecho-Vrieseling, Eline; Rieker, Claus; Fuchs, Sascha; Bleckmann, Dorothee; Esposito, Maria Soledad; Botta, Paolo; Goldstein, Chris; Bernhard, Mario; Galimberti, Ivan; Müller, Matthias; Lüthi, Andreas; Arber, Silvia; Bouwmeester, Tewis; van der Putten, Herman; Di Giorgio, Francesco Paolo  Author Correction: Transneuronal propagation of mutant huntingtin contributes to non-cell autonomous pathology in neurons  1546-1726  Nature neuroscience  JournalItem (Kommentare, Editorials, Rezensionen, Urteilsanmerk., etc. in einer wissensch. Zeitschr. 
4484296  Heindorf, Matthias; Arber, Silvia; Keller, Georg B.  Mouse Motor Cortex Coordinates the Behavioral Response to Unpredicted Sensory Feedback  0896-6273 ; 1097-4199  Neuron  Publication: JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) 
4500776  Heindorf, Matthias; Arber, Silvia; Keller, Georg B.  Mouse Motor Cortex Coordinates the Behavioral Response to Unpredicted Sensory Feedback  0896-6273 ; 1097-4199  Neuron  JournalItem (Kommentare, Editorials, Rezensionen, Urteilsanmerk., etc. in einer wissensch. Zeitschr. 
4486888  Ferreira-Pinto, Manuel J.; Ruder, Ludwig; Capelli, Paolo; Arber, Silvia  Connecting Circuits for Supraspinal Control of Locomotion  1097-4199  Neuron  Publication: JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) 
4482573  Arber, Silvia; Costa, Rui M.  Connecting neuronal circuits for movement  0036-8075 ; 1095-9203  Science  Publication: JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) 
   

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25/04/2024