Anti-TNF and skin inflammation in IBD: a new paradox in gastroenterology?
JournalItem (Reviews, Editorials, Rezensionen, Urteilsanmerkungen etc. in einer wissenschaftlichen Zeitschrift)
ID 4407469
Author(s) Niess, Jan Hendrik; Danese, Silvio
Author(s) at UniBasel Niess, Jan Hendrik
Year 2014
Title Anti-TNF and skin inflammation in IBD: a new paradox in gastroenterology?
Journal Gut
Volume 63
Number 4
Pages 533-5
Keywords Antibodies/*therapeutic use; Female; Humans; Inflammatory Bowel Diseases/*immunology; Interferon-gamma/*immunology; Interleukin-12/*immunology; Interleukin-17/*immunology; Interleukin-23/*immunology; Interleukins/*immunology; Male; Psoriasis/*immunology; Th1 Cells/*physiology; Tumor Necrosis Factor-alpha/*immunology; Inflammatory bowel disease; Tnf
Mesh terms Antibodies, therapeutic use; Female; Humans; Inflammatory Bowel Diseases, immunology; Interferon-gamma, immunology; Interleukin-12, immunology; Interleukin-17, immunology; Interleukin-23, immunology; Interleukins, immunology; Male; Psoriasis, immunology; Th1 Cells, physiology; Tumor Necrosis Factor-alpha, immunology
Abstract Meningothelial cells (MECs) are the cellular components of the meninges. As such, they provide important barrier function for the central nervous system (CNS) building the interface between neuronal tissue and the cerebrospinal fluid (CSF), and are also part of the immune response of the CNS. Human, immortalized MECs were analyzed by flow cytometry and confocal microscopy to study the uptake of apoptotic cells. Furthermore, cytokine and chemokine production by MECs was analyzed by cytokine array and ELISA. We found that MECs are highly active phagocytes able of ingesting and digesting large amounts of apoptotic cells. Furthermore, the uptake of apoptotic cells by MECs was immune suppressive via inhibiting the secretion of pro-inflammatory and chemoattractant cytokines and chemokines IL-6, IL-8, IL-16, MIF, and CXCL1, while increasing the secretion of anti-inflammatory IL-1 receptor antagonist by MECs. MECs respond with the secretion of anti-inflammatory cytokines and chemokines following the uptake of apoptotic cells potentially connecting these cells to processes important for the shut-down of immune responses in the brain.
Publisher British Medical Association
ISSN/ISBN 0017-5749 ; 1468-3288
Full Text on edoc No
Digital Object Identifier DOI 10.1136/gutjnl-2013-304683
PubMed ID
ISI-Number WOS:000332267500002
Document type (ISI) Journal Article, Comment

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