A Four-Step Synthesis of (±)-γ-Lycorane via Pd0-Catalyzed Double C(sp2)–H/C(sp3)

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A Four-Step Synthesis of (±)-γ-Lycorane via Pd0-Catalyzed Double C(sp2)–H/C(sp3)–H Arylation

JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)

ID	4405886
Author(s)	Rocaboy, Ronan; Dailler, David; Baudoin, Olivier
Author(s) at UniBasel	Baudoin, Olivier
Year	2018
Title	A Four-Step Synthesis of (±)-γ-Lycorane via Pd0-Catalyzed Double C(sp2)–H/C(sp3)–H Arylation
Journal	Organic Letters
Volume	20
Number	3
Pages / Article-Number	772-775
Abstract	An expedient synthesis of lycorine alkaloids is reported using a palladium(0)-catalyzed double C–X/C–H arylation as the key step. The selectivity of this reaction was controlled through the judicious choice of the two halogen atoms, and its generality was demonstrated through the construction of various substituted pyrrolophenanthridinones. A selective arene hydrogenation allowed for the completion of the synthesis of (±)-γ-lycorane in just four steps from commercially available precursors.
Publisher	American Chemical Society
ISSN/ISBN	1523-7060 ; 1523-7052
edoc-URL	https://edoc.unibas.ch/62336/
Full Text on edoc	Restricted
Digital Object Identifier DOI	10.1021/acs.orglett.7b03909
ISI-Number	000424729800070
Document type (ISI)	Article

06/05/2024

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