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Barbier-Negishi Coupling of Secondary Alkyl Bromides with Aryl and Alkenyl Triflates and Nonaflates
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 4405883
Author(s) Zhang, Ke-Feng; Christoffel, Fadri; Baudoin, Olivier
Author(s) at UniBasel Baudoin, Olivier
Year 2018
Title Barbier-Negishi Coupling of Secondary Alkyl Bromides with Aryl and Alkenyl Triflates and Nonaflates
Journal Angewandte Chemie International Edition
Volume 57
Number 7
Pages / Article-Number 1982-1986
Keywords cross-coupling; palladium; phosphine ligands; synthetic methods; transition-metal catalysis
Abstract A mild and practical Barbier-Negishi coupling of secondary alkyl bromides with aryl and alkenyl triflates and nonaflates has been developed. This challenging reaction was enabled by the use of a very bulky imidazole-based phosphine ligand, which resulted in good yields as well as good chemo- and site selectivities for a broad range of substrates at room temperature and under non-aqueous conditions. This reaction was extended to primary alkyl bromides by using an analogous pyrazole-based ligand.
Publisher Wiley
ISSN/ISBN 1433-7851 ; 1521-3773
edoc-URL https://edoc.unibas.ch/62334/
Full Text on edoc Restricted
Digital Object Identifier DOI 10.1002/anie.201711990
ISI-Number 000424212300042
Document type (ISI) Article
 
   

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