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Extreme exercise enhances chromogranin A levels correlating with stress levels but not with cardiac burden
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID
4399376
Author(s)
Nickel, T.; Vogeser, M.; Emslander, I.; David, R.; Heilmeier, B.; op den Winkel, M.; Schmidt-Trucksäss, A.; Wilbert-Lampen, U.; Hanssen, Henner; Halle, M.
OBJECTIVE: Stress and heart failure are associated with increased systemic levels of chromogranin A (CGA). Here we analyzed the effects of marathon running on systemic CGA levels and the association with cardiac burden and stress.
METHODS: We recruited 47 lean and obese runners for a 10week training program aiming at running a marathon. Heart rates, individual fitness and marathon finishing times were monitored. CGA, proBNP and troponin T levels were analyzed by ELISA.
RESULTS: We found a significant increase of CGA (+51%; p<0.01) in lean runners after marathon. The obese group showed the highest troponin T (0.22ng/ml; p<0.01) and proBNP (176.6ng/ml; p<0.01) levels. There were no correlations between proBNP, troponin T and CGA. An inverse correlation (r=-0.45; p<0.01) was found between CGA and finishing times.
CONCLUSION: Marathon running is associated with increased CGA levels. However, this does not seem to reflect cardiac burden but rather marathon induced stress.
