Data Entry: Please note that the research database will be replaced by UNIverse by the end of October 2023. Please enter your data into the system Thanks

Login for users with Unibas email account...

Login for registered users without Unibas email account...

ExAMIN YOUTH South Africa
Project funded by own resources
Project title ExAMIN YOUTH South Africa
Principal Investigator(s) Hanssen, Henner
Kruger, Ruan
Organisation / Research unit Faculty of Medicine,
Departement Sport, Bewegung und Gesundheit,
Departement Sport, Bewegung und Gesundheit / Präventive Sportmedizin (Hanssen)
Project Website
Project start 01.10.2018
Probable end 01.10.2022
Status Completed

Background: The impact of a sedentary and unhealthy lifestyle on cardiovascular health is well-documented, however the current obesity and hypertension trends among children is concerning. The ExAMIN Youth SA study aims to investigate the impact of lifestyle behaviors (physical fitness/activity, dietary intake and psychosocial factors) involved in early vascular aging among South African children. Methods: This study is an analytical, multidisciplinary, observational cohort study in a school-based setting. We aim to phenotype a cohort of ~1,000 primary school children (black and white boys and girls between ages 5-9 years) based on current clinical childhood conditions including hypertension and obesity. The primary phenotype is large artery stiffness and retinal microvascular diameters, both biomarkers of early vascular aging. The risk factors and mediators of early vascular aging and also responsible for the clinical conditions include physical inactivity, unhealthy diet, and life stress. Additionally, urinalysis and salivary analyses will be performed to identify biomarkers related to the pathophysiology of early vascular aging. Discussion: In line with the growing prevalence of obesity and hypertension responsible for the development of early vascular aging from childhood to adulthood, this study will address the critical areas in which we observe unfavorable arterial modulation related to dietary behaviors, physical inactivity, and early life stress. Implementation of novel biological markers may further contribute to our understanding of early cardiovascular adaptations in childhood, and aid in the development of primary prevention programs. Trial registration: The study was retrospectively registered on on 15 August 2019 (NCT04056377).

Keywords Childhood cardiovascular risk; vascular health; physical activity
Financed by Other funds

MCSS v5.8 PRO. 0.374 sec, queries - 0.000 sec ©Universität Basel  |  Impressum   |