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Identification of rare variants in KCTD13 at the schizophrenia risk locus 16p11.2
Journal
Psychiatric Genetics
Volume
26
Number
6
Pages / Article-Number
293-296
Abstract
Duplications in 16p11.2 are a risk factor for schizophrenia (SCZ). Using genetically modified zebrafish, Golzio and colleagues identified KCTD13 within 16p11.2 as a major driver of the neuropsychiatric phenotype observed in humans. The aims of the present study were to explore the role of KCTD13 in the development of SCZ and to provide a more complete picture of the allelic architecture at this risk locus. The exons of KCTD13 were sequenced in 576 patients. The mutations c.6G
