Analysis of genome-wide significant bipolar disorder genes in borderline personality disorder
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID 4377251
Author(s) Witt, Stephanie H.; Kleindienst, Nikolaus; Frank, Josef; Treutlein, Jens; Muhleisen, Thomas W.; Degenhardt, Franziska; Jungkunz, Martin; Krumm, Bertram; Cichon, Sven; Tadic, André; Dahmen, Norbert; Schwarze, Cornelia E.; Schott, Björn H.; Dietl, Lydia; Nöthen, Markus M.; Mobascher, Arian; Lieb, Klaus; Roepke, Stefan; Rujescu, Dan; Rietschel, Marcella; Schmahl, Christian; Bohus, Martin
Author(s) at UniBasel Cichon, Sven
Year 2014
Title Analysis of genome-wide significant bipolar disorder genes in borderline personality disorder
Journal Psychiatric Genetics
Volume 24
Number 6
Pages / Article-Number 262-5
Keywords Bipolar Disorder/*genetics; Borderline Personality Disorder/*genetics; *Genome-Wide Association Study; Humans
Mesh terms Bipolar Disorder, genetics; Borderline Personality Disorder, genetics; Genome-Wide Association Study; Humans
Abstract The objective of this study was to investigate the hypothesis that borderline personality disorder (BPD) and bipolar disorder (BD) share genetic variation through analysis of known genetic risk factors for BD in a well-characterized BPD case-control cohort. Genotyping of five genome-wide significant variants identified for BD (in CACNA1C, ANK3, and ODZ4) was performed in 673 BPD cases and 748 controls. A nominally significant association with BPD was found for rs1006737 in CACNA1C (P=0.0498). Sex-specific analysis showed that this signal was present only in women. This is the first report of an association between a BD risk gene and BPD where selection was not based on a priori hypotheses about its function, but on an unbiased hypothesis-free screening of the genome. Genome-wide association data of large samples of BPD are warranted and will eventually identify new risk genes and the overlap between BPD and BD if it exists.
Publisher Lippincott Williams & Wilkins
ISSN/ISBN 0955-8829 ; 1473-5873
Full Text on edoc No
Digital Object Identifier DOI 10.1097/YPG.0000000000000060
PubMed ID
ISI-Number WOS:000344918900005
Document type (ISI) Journal Article

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