A genome-wide association study of anorexia nervosa
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 4377184
Author(s) Boraska, Vesna; Franklin, Christopher S.; Floyd, James A.B.; Thornton, Laura M.; Huckins, Laura M.; Southam, Lorraine; Rayner, N. William; Tachmazidou, Ioanna; Klumpp, Kelly; Treasure, Janet; Lewis, Cathryn M.; Schmidt, Ulrike; Tozzi, Federica; Kiezebrink, Kirsty; Hebebrand, Johannes; Gorwood, Philip; Adan, Roger A. H.; Kas, Martin J. H.; Favaro, Angela; Santonastaso, Paolo; Fernández-Aranda, Fernando; Gratacòs, Mònica; Rybakowski, Filip; Dmitrzak-Weglarz, Monika; Kaprio, Jaakko; Keski-Rahkonen, Anna; Raevuori, Anu; Van Furth, Eric F.; Slof-Op 't Landt, Margarita; Hudson, James I.; Reichborn-Kjennerud, Ted; Knudsen, Gun Peggy S.; Monteleone, Palmiero; Kaplan, Allan S.; Karwautz, Andreas; Hakonarson, Hakon; Berrettini, Wade H.; Guo, Yiran; Li, Dong; Schork, Nicholas; Komaki, Gen; Ando, Tetsuya; Inoko, Hidetoshi; Esko, Tõnu; Fischer, Krista; Männik, Katrin; Metspalu, Andres; Baker, Jessica H.; Cone, Roger D.; Dackor, Jennifer; DeSocio, Janiece E.; Hilliard, Christopher E.; O'Toole, Julie K.; Pantel, Jacques; Szatkiewicz, Jin P.; Taico, Chrysecolla; Zerwas, Stephanie; Trace, Sara E.; Davis, Oliver S. P.; Helder, Sietske; Buhren, Katherina; Burghardt, Roland; de Zwaan, Martina; Egberts, Karin; Ehrlich, Stefan; Herpertz-Dahlmann, Beate; Herzog, Wolfgang; Imgart, Hartmut; Scherag, André; Scherag, Susann; Zipfel, Stephan; Boni, Claudette; Ramoz, Nicolas; Versini, Audrey; Brandys, Marek K.; Danner, Unna N.; de Kovel, Carolien; Hendriks, Judith; Koeleman, Bobby P. C.; Ophoff, Roel A.; Strengman, Eric; van Elburg, Annemarie A.; Bruson, Alice; Clementi, Maurizio; Degortes, Daniela; Forzan, Monica; Tenconi, Elena; Docampo, Elisa; Escaramis, Georgia; Jiménez-Murcia, Susana; Lissowska, Jolanta; Rajewski, Andrzej; Szeszenia-Dabrowska, Neonila; Slopien, Agnieszka; Hauser, Joanna; Karhunen, Leila; Meulenbelt, Ingrid; Slagboom, P. Eline; Tortorella, Alfonso; Maj, Mario; Dedoussis, George; Dikeos, Dimitris; Gonidakis, Fragiskos; Tziouvas, Konstantinos; Tsitsika, Artemis; Papezova, Hana; Slachtova, Lenka; Martaskova, Debora; Kennedy, James L.; Levitan, Robert D.; Yilmaz, Zeynep; Huemer, Julia; Koubek, Doris; Merler, Elisabeth; Wagner, Gudrun; Lichtenstein, Paul; Breen, Gerome; Cohen-Woods, Sarah; Farmer, Ann; McGuffin, Peter; Cichon, Sven; Giegling, Ina; Herms, Stefan; Rujescu, Dan; Schreiber, Stefan; Wichmann, H-Erich; Dina, Christian; Sladek, Rob; Gambaro, Giovanni; Soranzo, Nicole; Julia, Antonio; Marsal, Sara; Rabionet, Raquel; Gaborieau, Valerie; Dick, Danielle M.; Palotie, Aarno; Ripatti, Samuli; Widen, Elisabeth; Andreassen, Ole A.; Espeseth, Thomas; Lundervold, Astri J.; Reinvang, Ivar; Steen, Vidar M.; Le Hellard, Stephanie; Mattingsdal, Morten; Ntalla, Ioanna; Bencko, Vladimir; Foretova, Lenka; Janout, Vladimir; Navratilova, Marie; Gallinger, Steven; Pinto, Dalila; Scherer, Stephen W.; Aschauer, Harald; Carlberg, Laura; Schosser, Alexandra; Alfredsson, Lars; Ding, Bo; Klareskog, Lars; Padyukov, Leonid; Finan, Chris; Guillaume, Phillippe; Kalsi, Gursharan; Roberts, Marion; Logan, Darren W.; Peltonen, Leena; Ritchie, Graham R. S.; Barrett, Jeffrey C.; Wellcome Trust Case Control Consortium,; Estivill, Xavier; Hinney, Anke; Sullivan, Patrik F.; Collier, David A.; Zeggini, Eleftheria; Bulik, Cynthia M.
Author(s) at UniBasel Cichon, Sven
Year 2014
Title A genome-wide association study of anorexia nervosa
Journal Molecular Psychiatry
Volume 19
Number 10
Pages / Article-Number 1085-1094
Keywords Anorexia Nervosa/*genetics; Asian Continental Ancestry Group/genetics; Calcineurin/genetics; Carrier Proteins/genetics; Case-Control Studies; Cullin Proteins/genetics; European Continental Ancestry Group/genetics; Female; Genome-Wide Association Study; Guanine Nucleotide Exchange Factors/genetics; Humans; Japan; Male; Meta-Analysis as Topic; Nuclear Proteins/genetics; Polymorphism, Single Nucleotide
Abstract Anorexia nervosa (AN) is a complex and heritable eating disorder characterized by dangerously low body weight. Neither candidate gene studies nor an initial genome-wide association study (GWAS) have yielded significant and replicated results. We performed a GWAS in 2907 cases with AN from 14 countries (15 sites) and 14 860 ancestrally matched controls as part of the Genetic Consortium for AN (GCAN) and the Wellcome Trust Case Control Consortium 3 (WTCCC3). Individual association analyses were conducted in each stratum and meta-analyzed across all 15 discovery data sets. Seventy-six (72 independent) single nucleotide polymorphisms were taken forward for in silico (two data sets) or de novo (13 data sets) replication genotyping in 2677 independent AN cases and 8629 European ancestry controls along with 458 AN cases and 421 controls from Japan. The final global meta-analysis across discovery and replication data sets comprised 5551 AN cases and 21 080 controls. AN subtype analyses (1606 AN restricting; 1445 AN binge-purge) were performed. No findings reached genome-wide significance. Two intronic variants were suggestively associated: rs9839776 (P=3.01 x 10(-7)) in SOX2OT and rs17030795 (P=5.84 x 10(-6)) in PPP3CA. Two additional signals were specific to Europeans: rs1523921 (P=5.76 x 10(-)(6)) between CUL3 and FAM124B and rs1886797 (P=8.05 x 10(-)(6)) near SPATA13. Comparing discovery with replication results, 76% of the effects were in the same direction, an observation highly unlikely to be due to chance (P=4 x 10(-6)), strongly suggesting that true findings exist but our sample, the largest yet reported, was underpowered for their detection. The accrual of large genotyped AN case-control samples should be an immediate priority for the field.
Publisher Nature Publishing Group
ISSN/ISBN 1359-4184 ; 1476-5578
URL https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4325090/
edoc-URL https://edoc.unibas.ch/61529/
Full Text on edoc No
Digital Object Identifier DOI 10.1038/mp.2013.187
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/24514567
ISI-Number WOS:000343661700008
Document type (ISI) Article
 
   

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