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The 6-min walk test in heart failure: is it a max or sub-maximum exercise test?
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID 4376362
Author(s) Jehn, Melissa; Halle, Martin; Schuster, Tibor; Hanssen, Henner; Weis, Michael; Koehler, Friedrich; Schmidt-Trucksäss, Arno
Author(s) at UniBasel Hanssen, Henner
Schmidt-Trucksäss, Arno
Year 2009
Title The 6-min walk test in heart failure: is it a max or sub-maximum exercise test?
Journal European Journal of Applied Physiology
Volume 107
Number 3
Pages / Article-Number 317-23
Keywords Clinical exercise testing, Ventilatory response, Oxygen consumption, Exercise capacity
Mesh terms Aged; Analysis of Variance; Exercise Test, methods; Exercise Tolerance, physiology; Female; Heart Failure, physiopathology; Humans; Male; Middle Aged; Oxygen Consumption, physiology; Prognosis; Severity of Illness Index; Treatment Outcome
Abstract The aim of the study is to compare the cardiorespiratory response during the 6-min walk test (6MWT) with a symptom-limited cardiopulmonary exercise test (CPET) in patients with varying degrees of heart failure. Thirty-seven patients with heart failure (New York Heart Association I-III) were asked to complete a 6MWT and a CPET on a cycle ergometer. Respiratory gases were measured during both the tests and patients were grouped into tertiles according to their VO(2peak) reached during the CPET prior to performing statistical analysis of all other respiratory parameters. Patients were grouped into the following tertiles: Group 1 (VO(2peak) >25.2 ml/kg per min, N = 13), Group 2 (VO(2peak) >17.5-25.2 ml/kg per min), and Group 3 (VO(2peak) < or =17.5 ml/kg per min). Despite the good overall correlation between 6MWT VO(2) and CPET VO(2peak) (r = 0.72, P < 0.001), significant differences were seen within Groups 1 and 3 (P < 0.05). In Group 1, 6MWT VO(2) was significantly lower compared with CPET VO(2peak), whereas Group 3 showed significantly higher 6MWT VO(2) compared with CPET VO(2peak). In conclusion, the use of the 6MWT to evaluate exercise capacity in patients with heart failure is highly dependent on the degree of functional impairment. In patients with advanced heart failure, the 6MWT elicits a maximum exercise response, whereas it only constitutes a sub-maximal exercise test in patients with mild heart failure and no functional limitations. This must be taken into consideration when using the 6MWT in large epidemiological studies to evaluate therapy outcome and clinical prognosis in patients with varying degrees of clinical disabilities.
Publisher Springer
ISSN/ISBN 1439-6319 ; 1439-6327
Full Text on edoc No
Digital Object Identifier DOI 10.1007/s00421-009-1128-0
PubMed ID
ISI-Number WOS:000270280900007
Document type (ISI) Journal Article

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