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How pregnancy at early age protects against breast cancer
JournalItem (Reviews, Editorials, Rezensionen, Urteilsanmerkungen etc. in einer wissenschaftlichen Zeitschrift)
 
ID 4373872
Author(s) Meier-Abt, Fabienne; Bentires-Alj, Mohamed
Author(s) at UniBasel Bentires-Alj, Mohamed
Year 2014
Title How pregnancy at early age protects against breast cancer
Journal Trends in Molecular Medicine
Volume 20
Number 3
Pages 143-153
Keywords *Age Factors; Animals; Breast Neoplasms/*prevention & control; Cell Differentiation; Cell Proliferation; Epithelial Cells/metabolism; Female; Humans; Mammary Glands, Animal/cytology/metabolism; Mammary Glands, Human/cytology/metabolism; Mice; Parity; *Pregnancy; Stem Cells/metabolism; Transforming Growth Factor beta/metabolism; Wnt Signaling Pathway; TGFbeta signaling; Wnt signaling; breast development; hormone receptors; mammary stem/progenitor cells; pregnancy
Abstract Pregnancy at an early age has a strong protective effect against breast cancer in humans and rodents. Postulated mechanisms underlying this phenomenon include alterations in the relative dynamics of hormone and growth factor-initiated cell fate-determining signaling pathways within the hierarchically organized mammary gland epithelium. Recent studies in epithelial cell subpopulations isolated from mouse and human mammary glands have shown that early pregnancy decreases the proportion of hormone receptor-positive cells and causes pronounced changes in gene expression as well as decreased proliferation in stem/progenitor cells. The changes include downregulation of Wnt and transforming growth factor beta (TGFbeta) signaling. These new findings highlight the importance of cell-cell interactions within the mammary gland epithelium in modulating cancer risk and provide potential targets for breast cancer prevention strategies.
Publisher Elsevier
ISSN/ISBN 1471-4914 ; 1471-499X
edoc-URL https://edoc.unibas.ch/61373/
Full Text on edoc No
Digital Object Identifier DOI 10.1016/j.molmed.2013.11.002
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/24355762
ISI-Number WOS:000333512000003
Document type (ISI) Review
 
   

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