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Indoor bacteria and asthma in adults : a multicentre case-control study within ECRHS II
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID 4354945
Author(s) Pekkanen, Juha; Valkonen, Maria; Täubel, Martin; Tischer, Christina; Leppänen, Hanna; Kärkkäinen, Päivi M.; Rintala, Helena; Zock, Jan-Paul; Casas, Lidia; Probst-Hensch, Nicole; Forsberg, Bertil; Holm, Mathias; Janson, Christer; Pin, Isabelle; Gislason, Thorarinn; Jarvis, Debbie; Heinrich, Joachim; Hyvärinen, Anne
Author(s) at UniBasel Probst Hensch, Nicole
Year 2018
Title Indoor bacteria and asthma in adults : a multicentre case-control study within ECRHS II
Journal The European respiratory journal
Volume 51
Number 2
Pages / Article-Number 1701241
Abstract Both protective and adverse effects of indoor microbial exposure on asthma have been reported, but mostly in children. To date, no study in adults has used non-targeted methods for detection of indoor bacteria followed by quantitative confirmation.A cross-sectional study of 198 asthmatic and 199 controls was conducted within the European Community Respiratory Health Survey (ECRHS) II. DNA was extracted from mattress dust for bacterial analysis using denaturing gradient gel electrophoresis (DGGE). Selected bands were sequenced and associations with asthma confirmed with four quantitative PCR (qPCR) assays.15 out of 37 bands detected with DGGE, which had at least a suggestive association (p<0.25) with asthma, were sequenced. Of the four targeted qPCRs,; Clostridium; cluster XI confirmed the protective association with asthma. The association was dose dependent (aOR 0.43 (95% CI 0.22-0.84) for the fourth; versus; first quartile, p for trend 0.009) and independent of other microbial markers. Few significant associations were observed for the three other qPCRs used.In this large international study, the level of; Clostridium; cluster XI was independently associated with a lower risk of prevalent asthma. Results suggest the importance of environmental bacteria also in adult asthma, but need to be confirmed in future studies.
Publisher Munksgaard
ISSN/ISBN 0903-1936
Full Text on edoc No
Digital Object Identifier DOI 10.1183/13993003.01241-2017
PubMed ID
ISI-Number WOS:000424396500007
Document type (ISI) Article

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