Deciphering Basal Ganglia Sub-circuits involved in Motor and Cognitive Functions
Third-party funded project
Project title Deciphering Basal Ganglia Sub-circuits involved in Motor and Cognitive Functions
Principal Investigator(s) Tan, Kelly
Organisation / Research unit Departement Biozentrum / Physiopathology of basal ganglia neuronal subcircuits (Tan)
Project start 01.10.2018
Probable end 30.09.2019
Status Completed
Abstract

Parkinson’s disease is characterised by the degeneration of Dopamine neurons. The loss the dopamine neuromodulation leads to dysregulation of several synapses  and sub-circuits that are important for motor and cognitive functions. We investigate these dysfunctions at the level of cellular specificity, synaptic plasticity and behaviour. To do so we employ a range of state of the art technique including anatomical mapping, slice physiology, optogenetics and pharmacology, in vivo electrophysiology, in vivo calcium imaging and behaviour. Our main goal is to develop a circuiy-based strategy to compensate at the level of the synapse dynamic, for the motor and cognitive symptoms. 

Financed by Swiss National Science Foundation (SNSF)
Follow-up project of 3746910 Rewiring of inhibitory circuitries in Parkinson's disease
   

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10/08/2020