Parkinson’s disease is characterised by the degeneration of Dopamine neurons. The loss the dopamine neuromodulation leads to dysregulation of several synapses  and sub-circuits that are important for motor and cognitive functions. We investigate these dysfunctions at the level of cellular specificity, synaptic plasticity and behaviour. To do so we employ a range of state of the art technique including anatomical mapping, slice physiology, optogenetics and pharmacology, in vivo electrophysiology, in vivo calcium imaging and behaviour. Our main goal is to develop a circuiy-based strategy to compensate at the level of the synapse dynamic, for the motor and cognitive symptoms.