The goal of CASP, the Community Wide Experiment on the Critical Assessment of Techniques for Protein Structure Prediction, is to obtain an in-depth and objective assessment of our current abilities and inabilities in the area of protein structure prediction. To this end, participants have predicted as much as possible about a set of soon to be known structures. These true predictions, not ‘post-dictions’ made on already known structure, were assessed to explore if the models produced were similar to the corresponding experimental structure, and which methods are most effective. CAMEO uses weekly pre-released sequences from PDB for the continuous automated blind evaluation of structure prediction methods. This allows methods developers to continuously benchmark and improve methods, and users of models to select the most appropriate techniques.