Antiprotozoal sesquiterpene lactones and other constituents from Tarchonanthus camphoratus and Schkuhria pinnata
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 4325882
Author(s) Kimani, Njogu M.; Matasyoh, Josphat C.; Kaiser, Marcel; Brun, Reto; Schmidt, Thomas J.
Author(s) at UniBasel Kaiser, Marcel
Brun, Reto
Year 2018
Title Antiprotozoal sesquiterpene lactones and other constituents from Tarchonanthus camphoratus and Schkuhria pinnata
Journal Journal of natural products
Volume 81
Number 1
Pages / Article-Number 124-130
Abstract In continuation of a search for new antiprotozoal agents from plants of the family Asteraceae, Tarchonanthus camphoratus and Schkuhria pinnata have been investigated. By following the promising in vitro activity of the dichloromethane extracts from their aerial parts, bioassay-guided chromatographic isolation yielded two known sesquiterpene lactones (1 and 2) from T. camphoratus and 20 known compounds of this type from S. pinnata. From the latter, a new eudesmanolide, (1R*,5S*,6R*,7R*,8R*,10R*)-1-hydroxy-8-[5″-hydroxy-4'-(2″-hydroxyisovaleroyloxy)tigloyloxy]-3-oxoeudesma-11(13)-en-6,12-olide (3), and two new germacranolides, 3β-(2″-hydroxyisovaleroyloxy)-8β-(3-furoyloxy)costunolide (14) and 1(10)-epoxy-3β-hydroxy-8β-[5'-hydroxy-4'-(2″-hydroxyisovaleroyloxy)tigloyloxy]costunolide (16), were obtained. Additionally, the flavonoid pectolinarigenin (24) and 3-hydroxy-4,5-dimethoxybenzenepropanol (25) were also isolated from S. pinnata. The compounds were characterized by analysis of 1D and 2D NMR spectroscopic and HR/MS data. In vitro antitrypanosomal activity and cytotoxicity against mammalian cells (L6 cell line) were evaluated for all the compounds. Santhemoidin A (13) and 3β-(2″-hydroxyisovaleroyloxy)-8β-(3-furoyloxy)costunolide (14) were the most active compounds found in this study, with IC50 values of 0.10 and 0.13 μM against Trypanosoma brucei rhodesiense trypomastigotes and selectivity indices of 20.5 and 29.7, respectively.
Publisher American Society of Pharmacognosy
ISSN/ISBN 0163-3864
edoc-URL https://edoc.unibas.ch/60962/
Full Text on edoc No
Digital Object Identifier DOI 10.1021/acs.jnatprod.7b00747
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/29244495
ISI-Number WOS:000423778900018
Document type (ISI) Article
 
   

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