Architecture of the human mTORC2 core complex
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 4315217
Author(s) Stuttfeld, E.; Aylett, C. H. S.; Imseng, S.; Boehringer, D.; Scaiola, A.; Sauer, E.; Hall, M. N.; Maier, T.; Ban, N.
Author(s) at UniBasel Maier, Timm
Stuttfeld, Edward
Imseng, Stefan
Hall, Michael N.
Year 2018
Title Architecture of the human mTORC2 core complex
Journal eLife
Volume 7
Pages / Article-Number e33101
Abstract

The mammalian target of rapamycin (mTOR) is a key protein kinase controlling cellular metabolism and growth. It is part of the two structurally and functionally distinct multiprotein complexes mTORC1 and mTORC2. Dysregulation of mTOR occurs in diabetes, cancer and neurological disease. We report the architecture of human mTORC2 at intermediate resolution, revealing a conserved binding site for accessory proteins on mTOR and explaining the structural basis for the rapamycin insensitivity of the complex.

Publisher eLife Sciences Publications
ISSN/ISBN 2050-084X
edoc-URL https://edoc.unibas.ch/62883/
Full Text on edoc Available
Digital Object Identifier DOI 10.7554/eLife.33101
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/29424687
ISI-Number WOS:000426766500001
Document type (ISI) Article
 
   

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