Antibodies are crucial for the intact function of the human immune system. For example, they are responsible for the body’s defense against bacteria and cancer cells, but are also implicated in a variety of neuropsychiatric disorders. The present driver-project aims at identifying rare antibodies that will help elucidating mechanisms of disease and help identifying suitable targets for drug discovery. This will be achieved by an unprecedented high-throughput search for auto-antibodies in blood samples of thousands of participants. The Transfaculty Research Platform Molecular and Cognitive Neurosciences represents Basel’s involvement in this  Zurich-Basel alliance project. The Platform contributes with a unique combination of functional and structural brain imaging, genetic, behavioral, and biological data from thousands of healthy young participants who underwent detailed neuropsychological assessments. The intelligent interconnection of this database information with the data arising from the large, unselected patient cohort of the University Hospital Zurich will be crucial for the informed decisions that will result in the prioritization of novel drug targets.