A nor-diterpene from Salvia sahendica leaves
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID 4220294
Author(s) Mofidi Tabatabaei, Sahar; Salehi, Peyman; Moridi Farimani, Mahdi; Neuburger, Markus; De Mieri, Maria; Hamburger, Matthias; Nejad-Ebrahimi, Samad
Author(s) at UniBasel Neuburger, Markus
de Mieri, Maria
Hamburger, Matthias
Year 2017
Year: comment 2017
Title A nor-diterpene from Salvia sahendica leaves
Journal Natural Product Research
Volume 31
Number 15
Pages / Article-Number 1758-1765
Abstract Phytochemical investigation of n -hexane extract of Salvia sahendica by normal phase column chromatography resulted in the isolation of six compounds. Structures were established by 1D and 2D NMR spectroscopy, and HRMS, as a new norditerpene 1 , and known terpenoids, sclareol ( 2 ), oleanolic acid ( 3 ), ╬▓-sitosterol ( 4 ), salvigenin ( 5 ) and 3 ╬▒ -hydroxy-11 ╬▒ ,12 ╬▒ -epoxyoleanan-28,13 ╬▓ -olide ( 6 ). The absolute configuration of 1 was confirmed by a combination of X-ray single crystal analysis and electronic circular dichroism spectroscopy. In vitro cytotoxic activity on breast cancer cell line (MDA-MB-231) and also the antimicrobial activity of the pure compounds were tested against Staphylococcus aureus , Bacilus cereus and Escherichia coli.
Publisher Taylor & Francis
ISSN/ISBN 1478-6419 ; 1478-6427
edoc-URL http://edoc.unibas.ch/59098/
Full Text on edoc No
Digital Object Identifier DOI 10.1080/14786419.2017.1290619
ISI-Number WOS:000404789700007
Document type (ISI) Article

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