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Marathon performance but not BMI affects post-marathon pro-inflammatory and cartilage biomarkers
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 4179941
Author(s) Mündermann, Annegret; Geurts, Jeroen; Hügle, Thomas; Nickel, Thomas; Schmidt-Trucksäss, Arno; Halle, Martin; Hanssen, Henner
Author(s) at UniBasel Geurts, Jeroen
Schmidt-Trucksäss, Arno
Mündermann, Annegret
Hanssen, Henner
Year 2017
Title Marathon performance but not BMI affects post-marathon pro-inflammatory and cartilage biomarkers
Journal Journal of sports sciences
Volume 35
Number 7
Pages / Article-Number 711-718
Mesh terms Adult; Biomarkers, blood; Body Mass Index; C-Reactive Protein, metabolism; Cartilage, metabolism; Cartilage Oligomeric Matrix Protein; Humans; Inflammation, blood; Interleukin-6, blood; Male; Physical Endurance, physiology; Running, physiology; Tumor Necrosis Factor-alpha, blood
Abstract We tested the hypothesis that changes in serum cartilage oligomeric matrix protein (COMP), tumour necrosis factor α (TNF-α), interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hsCRP) concentration after regular endurance training and running a marathon race depend on body mass index (BMI) and/or on marathon performance. Blood samples were collected from 45 runners of varying BMI and running experience before and after a 10-week marathon training programme and before, immediately and 24 h after a marathon race. Serum biomarker concentrations, BMI and marathon finishing time were measured. The mean (95% confidence interval (CI)) changes from before to immediately after the marathon were COMP: 4.09 U/L (3.39-4.79 U/L); TNF-α: -1.17 mg/L (-2.58 to 0.25 mg/L); IL-6: 12.0 pg/mL (11.4-12.5 pg/mL); and hsCRP: -0.08 pg/mL (-0.14 to -0.3 pg/mL). The mean (95% CI) changes from immediately after to 24 h after the marathon were COMP: 0.35 U/L (-0.88 to 1.57 U/L); TNF-α: -0.43 mg/L (-0.99 to 0.13 mg/L); IL-6: -9.9 pg/mL (-10.5 to -9.4 pg/mL); and hsCRP: 1.52 pg/mL (1.25-1.79 pg/mL). BMI did not affect changes in biomarker concentrations. Differences in marathon finishing time explained 32% of variability in changes in serum hsCRP and 28% of variability in changes in serum COMP during the 24 h recovery after the marathon race (P < 0.001). Slower marathon finishing time but not a higher BMI modulates increases in pro-inflammatory markers or cartilage markers following a marathon race.
Publisher Francis & Taylor
ISSN/ISBN 0264-0414 ; 1466-447X
edoc-URL http://edoc.unibas.ch/58573/
Full Text on edoc Available
Digital Object Identifier DOI 10.1080/02640414.2016.1184301
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/27167978
ISI-Number WOS:000394351100013
Document type (ISI) Journal Article
 
   

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17/06/2024