Anxiety disorders before birth and self-perceived distress during pregnancy : associations with maternal depression and obstetric, neonatal and early childhood outcomes
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 417904
Author(s) Martini, Julia; Knappe, Susanne; Beesdo-Baum, Katja; Lieb, Roselind; Wittchen, Hans-Ulrich
Author(s) at UniBasel Lieb, Roselind
Year 2010
Title Anxiety disorders before birth and self-perceived distress during pregnancy : associations with maternal depression and obstetric, neonatal and early childhood outcomes
Journal Early human development : an international journal concerned with the continuity of fetal and postnatal life
Volume 86
Number 5
Pages / Article-Number 305-10
Keywords Anxiety disorders, Distress, Pregnancy, Obstetric, Neonate
Abstract

Background: Maternal perinatal mental health has been shown to be associated with adverse consequences for the mother and the child. However, studies considering the effect of DSM-IV anxiety disorders beyond maternal self-perceived distress during pregnancy and its timing are lacking.

Aims: To examine the role of maternal anxiety disorders with an onset before birth and self-perceived distress during pregnancy for unfavourable maternal, obstetric, neonatal and childhood outcomes.

Study design: DSM-IV mental disorders and self-perceived distress of 992 mothers as well as obstetric, neonatal and childhood outcomes of their offspring were assessed in a cohort sampled from the community using the Munich-Composite International Diagnostic Interview. Logistic regression analyses revealed associations (odds ratios) between maternal anxiety disorders and self-perceived distress during pregnancy with maternal depression after birth and a range of obstetric, neonatal and childhood psychopathological outcomes.

Results: Lifetime maternal anxiety disorders were related to offspring anxiety disorders, but not to offspring externalizing disorders. Analyses focussing on maternal DSM-IV anxiety disorders before birth yielded associations with incident depression after birth. In addition, self-perceived distress during pregnancy was associated with maternal depression after birth, preterm delivery, caesarean section, separation anxiety disorder, ADHD, and conduct disorder in offspring.

Conclusion: Findings confirm the transmission of anxiety disorders from mother to offspring. Apart from maternal anxiety, self-perceived distress during pregnancy also emerged as a putative risk factor for adverse outcomes. The finding that maternal anxiety disorders before birth yielded less consistent associations, suggests that self-perceived distress during pregnancy might be seen as a putative moderator/mediator in the familial transmission of anxiety.

Publisher Elsevier
ISSN/ISBN 0378-3782
edoc-URL http://edoc.unibas.ch/dok/A5840744
Full Text on edoc No
Digital Object Identifier DOI 10.1016/j.earlhumdev.2010.04.004
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/20547016
ISI-Number WOS:000280221300009
Document type (ISI) Journal Article
 
   

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