A new antifungal and antiprotozoal bibenzyl derivative from Gavilea lutea
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 4160333
Author(s) Cretton, Sylvian; Oyarzún, Alejandra; Righi, Davide; Sahib, Lamia; Kaiser, Marcel; Christen, Philippe; Fajardo, Victor
Author(s) at UniBasel Kaiser, Marcel
Year 2018
Title A new antifungal and antiprotozoal bibenzyl derivative from Gavilea lutea
Journal Natural Product Research
Volume 32
Number 6
Pages / Article-Number 695-701
Abstract A new bibenzyl derivative (4), together with two glycosylated flavonoids (1 and 2), batatasin III (3) and the phenanthrene isohircinol (5) were isolated from the aerial parts of Gavilea lutea. Their structures were elucidated on the basis of spectroscopic studies including 1D and 2D NMR, UV, IR and HRESIMS. All isolated compounds were evaluated for their antifungal activity towards Candida albicans. The new compound 4 showed inhibitory activity with a MIQ of 50 μg. In addition, compound 4 exhibited a selective activity (IC50 = 2.3 μg/mL) against Leishmania donovani.
Publisher Taylor & Francis
ISSN/ISBN 1478-6419 ; 1478-6427
edoc-URL http://edoc.unibas.ch/58375/
Full Text on edoc No
Digital Object Identifier DOI 10.1080/14786419.2017.1338287
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/28595455
ISI-Number MEDLINE:28595455
Document type (ISI) Journal Article
 
   

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