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A Secondary Structural Element in a Wide Range of Fucosylated Glycoepitopes
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 4156338
Author(s) Aeschbacher, Thomas; Zierke, Mirko; Smieško, Martin; Collot, Mayeul; Mallet, Jean-Maurice; Ernst, Beat; Allain, Frédéric H.-T.; Schubert, Mario
Author(s) at UniBasel Ernst, Beat
Zierke, Mirko
Smiesko, Martin
Year 2017
Title A Secondary Structural Element in a Wide Range of Fucosylated Glycoepitopes
Journal Chemistry - A European Journal
Volume 23
Number 48
Pages / Article-Number 11598-11610
Abstract The increasing understanding of the essential role of carbohydrates in development, and in a wide range of diseases fuels a rapidly growing interest in the basic principles governing carbohydrate-protein interactions. A still heavily debated issue regarding the recognition process is the degree of flexibility or rigidity of oligosaccharides. Combining NMR structure determination based on extensive experimental data with DFT and database searches, we have identified a set of trisaccharide motifs with a similar conformation that is characterized by a non-conventional C-H⋅⋅⋅O hydrogen bond. These motifs are present in numerous classes of oligosaccharides, found in everything from bacteria to mammals, including Lewis blood group antigens but also unusual motifs from amphibians and marine invertebrates. The set of trisaccharide motifs can be summarized with the consensus motifs X-β1,4-[Fucα1,3]-Y and X-β1,3-[Fucα1,4]-Y-a secondary structure we name [3,4]F-branch. The wide spectrum of possible modifications of this scaffold points toward a large variety of glycoepitopes, which nature generated using the same underlying architecture.
Publisher Wiley
ISSN/ISBN 0947-6539 ; 1521-3765
edoc-URL http://edoc.unibas.ch/58313/
Full Text on edoc No
Digital Object Identifier DOI 10.1002/chem.201701866
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/28654715
ISI-Number WOS:000408308200021
Document type (ISI) Article
 
   

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29/03/2024