Anaerobic Origin of Ergothioneine

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Anaerobic Origin of Ergothioneine

JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)

ID	4156318
Author(s)	Burn, Reto; Misson, Laëtitia; Meury, Marcel; Seebeck, Florian P.
Author(s) at UniBasel	Seebeck, Florian Peter
Year	2017
Title	Anaerobic Origin of Ergothioneine
Journal	Angewandte Chemie International Edition
Volume	56
Number	41
Pages / Article-Number	12508-12511
Abstract	Ergothioneine is a sulfur metabolite that occurs in microorganisms, fungi, plants, and animals. The physiological function of ergothioneine is not clear. In recent years broad scientific consensus has formed around the idea that cellular ergothioneine primarily protects against reactive oxygen species. Herein we provide evidence that this focus on oxygen chemistry may be too narrow. We describe two enzymes from the strictly anaerobic green sulfur bacterium Chlorobium limicola that mediate oxygen-independent biosynthesis of ergothioneine. This anoxic origin suggests that ergothioneine is also important for oxygen-independent life. Furthermore, one of the discovered ergothioneine biosynthetic enzymes provides the first example of a rhodanese-like enzyme that transfers sulfur to non-activated carbon.
Publisher	Wiley
ISSN/ISBN	1433-7851 ; 1521-3773
edoc-URL	http://edoc.unibas.ch/58307/
Full Text on edoc	No
Digital Object Identifier DOI	10.1002/anie.201705932
PubMed ID	http://www.ncbi.nlm.nih.gov/pubmed/28786519
ISI-Number	WOS:000411810600013
Document type (ISI)	Article

19/04/2024

Research Database / FORSCHUNGSDATENBANK