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Oxytocin and Autism Spectrum Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 4152793
Author(s) Ooi, Yoon Phaik; Weng, Shih-Jen; Kossowsky, Joe; Gerger, Heike; Sung, Min
Author(s) at UniBasel Ooi, Yoon Phaik
Kossowsky, Joe
Gerger, Heike
Year 2017
Title Oxytocin and Autism Spectrum Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Journal Pharmacopsychiatry
Volume 50
Number 1
Pages / Article-Number 5-13
Mesh terms Autism Spectrum Disorder, drug therapy; Databases, Bibliographic, statistics & numerical data; Humans; Oxytocics, therapeutic use; Oxytocin, therapeutic use; Randomized Controlled Trials as Topic
Abstract Aim: Oxytocin presents an exciting potential to target the core symptoms of autism spectrum disorder (ASD) pharmacologically in an easily administered, cost-effective form with possibly minimal adverse effects. But, there are still major gaps in this area of research. This paper reviewed randomized controlled trials (RCTs) examining the effects of oxytocin administration on social cognition and restricted, repetitive behaviors in individuals with an ASD. Method: Electronic literature searches were conducted from PsycINFO, PubMed, Web of Knowledge, and EMBASE for RCTs published through June 2015. Results: 12 RCTs were included in this review. 7 out of the 11 studies that examined social cognition reported improvements. Additionally, one out of the 4 studies on restricted, repetitive behaviors, reported improvements following oxytocin administration. However, results from our meta-analyses suggest that oxytocin has no significant effect on these 2 domains. Conclusion: Previous evidence revealed mixed findings about the effects of oxytocin on ASD. Given the limited number of RCTs, our summary of findings on the effectiveness of oxytocin on ASD should still be considered tentative.© Georg Thieme Verlag KG Stuttgart · New York.
Publisher Thieme
ISSN/ISBN 0720-4280
edoc-URL http://edoc.unibas.ch/58277/
Full Text on edoc No
Digital Object Identifier DOI 10.1055/s-0042-109400
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/27574858
ISI-Number 27574858
Document type (ISI) Review
 
   

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